Dr. Joel Rosen: Welcome back once again to another edition of your adrenal fix where we teach exhausted and burnt-out adults the truth about their health so that they can get their energy back quickly. And again, what another pleasure that I have here today with Dr. Bob Miller, this is our third edition. But each time we do it, there’s so much more information to go over.
And that’s why I reached out to him again, but Bob is a traditional naturopath specializing in the field of genetics specific nutrition, and he’s earned his naturopathic degree from Trinity School of Natural Health, he opened his tree of life and has served naturopathic traditional approaches for 27 years. And for the past several years, he’s been engaged exclusively with the functional nutritional genetic variants and related research, Bob, I know I could go on and on, but we want to give the listener some incredible value today. So thank you so much for your time.
Dr. Bob Miller: Oh, it was an honor to be here, and so much fun to work with people like you who understand this and see the value of it and want to pass it on to their viewers. So we’re gonna have some fun today.
Dr. Joel Rosen: Excellent. Yes, I appreciate that. So I will be quite honest. And I haven’t been on every single one of your webinars. But what I do is because you have a archive, I’ll really go down those archives and really go in sort of a binge, if you will. So I’ve been on a binge recently, and like, I got to reach out to Bob, because there’s so much more that we know.
And I think it’s probably just best for you to take over the steering wheel and tell us what you’ve been learning about environmental factors that overlap with genetic susceptibility that create these perfect storms of people that are getting sicker and sicker and sicker and seeing more and more people that have very little answers for them. And maybe just take it away from there, Bob.
Dr. Bob Miller: Okay, sounds like a plan. I’m gonna do a screen share here and see, there we go. You’re seeing the screen. Okay. Yep, we’re seeing the screen. Okay, the two things we want to talk about today as grantees, and ferroptosis. And these may be terms that some of your listeners may have never even heard of before. And we’re going to be trying to explain what they are, how we get there. And then, of course, what we can do for it. And of course, you know, I was mentioning, this is educational, informational only, we’re not telling people how to diagnose or treat any disease.
So as I often say, this is the 3d chess game played underwater, because a lot of times people are looking for, oh, what’s the snip? What’s the gene? And then what do I do for it, and I’m learning over time, that it’s much more complex than that. I mean, there are a couple of snips in genetics that might be related to disease. But many of the things we’re seeing today are just, as you mentioned, tired adrenals worn out, because they’re making so much mast cells and histamine.
And I believe these are two pathways that will create that the production of something called grantees and ferroptosis. But as you mentioned, this is more than just genetics, its environmental factors. There’s an old saying of genetics loads, the gun environment pulls the trigger, and we’re being exposed to so many new environmental factors, you’ll you’ll get a kick out of this, one of my jokes is when I, when I talk to people, I’ll say, you know, I was born in 1954.
And that means I was born on a different planet than we are today. When I was, when I was born, there was no such thing as high fructose corn syrup. We didn’t give the animals growth hormones, we didn’t genetically modify the foods. We didn’t have all the Wi Fi and cell phones. Our waters weren’t polluted with plastics, we didn’t have all the agricultural chemicals. We are just living in a soup of chemicals that nobody’s ever done any long term studies as to how they impact us. And when you look at how people are getting sicker, I mean, autism used to be one out of 1000.
Now, it’s one out of 4445. You know, when I was young, we used to call it adult onset diabetes. Now children are getting autoimmune disease is going through the roof. Something is happening. Our genetics haven’t changed. They’re the same as they were 100 years ago. But the environment has changed drastically. And unfortunately, some people have genetic predispositions that they can’t handle that as well. That’s why you’ll see two people living in a house.
And one person is terribly impacted by the mold. And the other one says, this is all in your head because I don’t feel a thing. And when they don’t feel anything, they don’t know that it’s that it’s real. But it really is, and the environmental factors will affect one person more than another. And that’s what we’re going to talk about here today, Dr. Rosen, how the environmental factors are impacting those with some less than optimal genetic detoxification.
Now, one of the first things we want to talk about his grantees and I would imagine, this is a term a lot of people have never heard as an interesting name, regulated upon activation, normal T cells expressed and secreted that is quite the quite the phrase, but it’s a powerful pro inflammatory mediator of the chemotactic cytokine chemokine family. And it just says your regulates the mobilization and survival of immune inflammatory cells from the bloodstream into tissues, and other areas of injury and infection. The rant is associated with several detrimental effects or to use grossest liver disease, viral infections.
And anything that interferes or slows down this ranty is associated with improved outcomes. So here’s how it’s created. Platelets, macrophages, epithelial cells, T lymphocytes, and it stimulates histamine secretion by mast cells. Now, Dr. Rosen I’m sure you’re seeing so many people with high levels of histamine coming into your office on a regular basis. Mike Mike, correct on that, correct? Yes, absolutely. And it regulates T cells, macrophages, Isana, fills and basophils to the sites of inflammation.
Now, I’m gonna go through these rather quickly. I’m not going to read all the slides, but just to give some ideas of some of the conditions that the scientists are believing are related to ratties. It’s related to hepatic injury, that’s your, your liver promotes fibrosis, by modulating hepatic inflammation, so it can damage the liver. It’s associated with autism spectrum disorder. So the hypothesis is that altered chemokine levels are involved in in with autism spectrum disorder.
It’s related to just inflammation grantees plays a fundamental role in histamine and serotonin generation and cell function and mast cells. Now you have a sophisticated audience here who has listened to you about about the adrenals. And we’ll get into this a little bit later. But as we all know, the adrenals need to make the cortisol that deals with the histamine.
So anything that creates more histamine is going to stress the adrenals. In a study of eczema grantees, and its receptors were shown to play potentially important roles in the infiltration, the ongoing chronic inflammation of the atopic eczema also reflects the severity of the disease. It controls the recruitment of leukocytes within the vascular wall, so it may have a relationship to arteriosclerosis inflammatory bowel disease, when they looked at the colonic tissue with patients such as Crohn’s disease, there was significant redundancy in the generation of the signals in chronic inflammation from grantees viral lung disease.
So this, this was made quite well known by a physician who was studying COVID And he found the rantings was often very high, Dr. Patterson, and a study of 10 terminally ill critical COVID-19 patients, profound elevation of interleukin six, that’s that cytokine, storm, and ranty is the infection of respiratory epithelial cells equals an upregulation of that Randy’s secretion. So there does seem to be a relationship between serious COVID and high levels of grantees.
And we’ll actually very soon be going through the the pathway maps and shows how that works. diagnosis of prostate cancer was significantly associated with the grantees. And this study says are results in previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in pro inflammatory genes may be important in prostate cancer development. So those are some of the things that that can cause it now. Don’t be too intimidated by this chart. We’re going to take you through step by step and show you what’s what’s happening.
Let me grab the the drawing tool here. And we will do a little bit of drawing. Alright, I want to bring your attention to TNF a tumor necrosis factor alpha. One of the things I like to say about this enzyme is that this is our friend, unless it isn’t, and what I mean by that, when we’re faced with a pathogen of any kind, that we need to kill or even a cancer cell, tumor necrosis factor comes to the rescue. It stimulates something called NF kappa B which is inflammatory. Then it stimulates the KNOX enzyme NADPH oxidase.
And you know, Dr. Rosen, I’ve been I’ve been talking about NOx for for years, I’ll just do a little explanation of that. NADPH oxidase is a fascinating enzyme. It is part of our immune system. It’s there to come to the rescue, to create mast cells and histamine. When there’s some bad guy in the body that we need to eradicate. Animal studies show if you knock this guy out, short period of time the animal dies of infection can’t survive. But there are now so many environmental factors that are old we’re stimulating NOx.
And this is why we’re seeing so much autoimmune disease. Now, let me back up here you’ll notice that mycotoxins, virus, Clostridium Lyme disease, lipid polysaccharides, all will stimulate this tnfa. So if we’re in chronic mycotoxin exposure, and there’s there’s debate on this, but no, Dr. Dietrich Klinghardt has hypothesized that Wi Fi and cell phones is making mycotoxins stronger. And just for me, in my own health coaching, so many of the individuals who are struggling, we find out they’re living in mold, and they have mycotoxins. Are you finding the same thing?
Dr. Joel Rosen: Yeah, absolutely. And to your point, the exactly the EMFs, that they have the genetic weaknesses on, create that perfect storm even further.
Dr. Bob Miller: Absolutely. Now, people that are born in England, Ireland, and sometimes Germany and Ashkenazi Jewish, many times have genetics that they absorb more iron. And you and I were just talking before the before the call that I need to add more to this, there’s other genes related to this. But anytime you have extra iron, that will also stimulate Tufa.
And we’ll get a little bit more into that when we when we talked about ferroptosis. Now the body is very amazing. In that, we also have mechanisms to slow this all down. There is an enzyme called cert, one that inhibits NF kappa B and NOx holds it back. So what an amazing intelligence there is in the body, Dr. Rosen, that this cert, one will say, you know, I think you’re getting a little carried away here. Let’s just hold this back a little bit. Let’s not get too carried away with inflammation.
There is one snip of one RS number, which is a genetic mutation that can down regulate certain one. But we’re going to look back someday and say, oops, if you remember earlier, I said, I was born on a different planet when there was no high fructose corn syrup. We’re going to look back on high fructose corn syrup and say, What are we thinking? Because it down-regulates cert one.
So no wonder we might be seeing so many issues today. And unfortunately, if you look at the foods that have high fructose corn syrup, it’s pretty amazing. It only came about in the mid-70s. And the use of it has just increased dramatically. So high fructose corn syrup isn’t good for anyone. But particularly if you have that one cert one mutation where this is weak, you really need to avoid high fructose corn syrup. Now there is another enzyme called heme oxygenase H O one and H O two.
And it makes something called Billy Verdun and Billy Rubin and people might be saying, well, Billy Rubin isn’t that why? When babies are born, sometimes they’re yellow and they’re put under a lamp. And Billy Rubin if that goes too high, isn’t that an indication of liver disease?
Absolutely. But interestingly, a small amount of bilirubin. This blew me away Dr. Oz when I saw this research, it inhibits tumor necrosis factor, inhibits NF kappa B inhibits NOx and inhibits il six. So we didn’t talk about yet inhibits all of those. Now, you can have genetic mutations on heme oxygenase one. There’s also an enzyme called nerf to NRF two that stimulates heme oxygenase.
You can have mutations here. I keep one enzyme this gets a little complicated. It inhibits the nerve to but it’s kind of like a valve that senses when there’s inflammation and what it does it releases the nerve to but you can have genetic mutations that nerve to is up regulated. Now interestingly, there’s an enzyme called il 10. That supports nerve two. But if you’re exposed to a mycotoxin, called citrinin, that citrinin can inhibit interleukin 10. So there are some mycotoxins that will stimulate inflammation.
Some mycotoxins that will leave in fight against your body to stop the inflammation. Then this whole thing needs something called heme. And there are eight steps that we go through to make that heme and we can have genetic mutations along the way here that will impede that. And then also, there’s growing concern that roundup glyphosate may inhibit glycine is debated.
Now some people say it does. Some people say it doesn’t. It inhibits the glycine which is needed for this process to work. Often when this is not working well, we get what’s called hangry, where we’ll get agitated, fearful, and worried. And then we have something to eat, particularly a carbohydrate, and we feel better. And then this is sustainable COA from the Krebs cycle.
So if there’s anything impacting mitochondrial function, where we don’t have enough glycine, or we have glyphosate, or we have genetic mutations long here, we don’t make enough heme. And then finally, there’s a very fascinating enzyme called por that donates something called NADPH. To the heme oxygenase enzymes for them to do their work. Talk about a 3d chess game here, Dr. Rosen. There’s an enzyme called fad, which is dependent upon riboflavin.
You can have genetic mutations in your riboflavin. You can have genetic mutations on por G six PD is a genetic mutation that often occurs in southern Italians, Native Americans, Africans. So many people from South America where you don’t make enough NADPH. And yet even further complicated, it’s controlled by nerf two and keep one. So you can see how nerf two plays a role in giving the body what it needs plus controlling it.
Now, we spent about maybe 90 seconds on that if somebody really finds this fascinating. If you go on YouTube, and type Carnahan, C AR n d h, an n for Dr. Joe Carnahan, he, Dr. Carnahan, and I spent about an hour and a half just on this pathway here, pulling up all the peer-reviewed studies on what I believe Rubin does, just blew me away when I learned about it because I just thought bilirubin is a bad thing.
So what I’m saying here now is that when we get these environmental factors, made worse by people with genetic mutations, and if I didn’t mention, you can actually have genetic mutations on TNF that make it trigger-happy, overactive, you might have some iron, you’re eating a lot of high fructose corn syrup, you’re being exposed to a lot of glyphosates, you got mutations here, you are not able to hold back that inflammation, then we get mast cells. And I’m sure everybody’s now heard of mast cell activation syndrome. What? What percentage of the people you see Dr. Rosen Do you think you see with with mast cell activation?
Dr. Joel Rosen: Yeah, I mean, I would go as far as say 100. Right, because by the time they come to you and me, they have already exhausted a lot of their health challenges. And at some level, whether they have the gene snips or not, which they’ll have some form of a combination of the perfect storm of those environmental challenges. Because we live in a world that was different than the one you were born in. Ultimately, I’d say probably every single one of them would go as far as saying that to Bob.
Dr. Bob Miller: Yeah, I would say 85 90% of the folks that I see a mast cell activation. In other words, if somebody doesn’t know what that is, mast cells, again, they’re our friend unless they aren’t, meaning that they’re there to kill pathogens, or like the police or the military. We wouldn’t live without them. But when they become over-activated, they start attacking the body. There are also genes called the kit genes that can be mutated that are upregulation, as well. Then we make histamine.
And I’m sure, probably a third of the people listening to this at some time or another in their life have trouble with histamine. Well, if you’re overproducing it, that’s one thing but there are also enzymes called ADP, one that makes an enzyme called data mine oxidase that degrades it, and there’s something called histamine and methyl transferase. That takes his time and turns it into a form that I don’t have listed here.
That then has to be cleared by my OA and my OB interestingly controlled by a certain one, and then the aldehydes are the last step. So talking about the adrenals. The adrenal glands are very much involved in trying to deal with all this histamine through cortisol. We’ll show that in a little more detail later. So your adrenals are going to get worn out if this is constantly a problem. Now the next thing is that histamine stimulates an enzyme called ions inducible nitric oxide synthase. So let’s talk about nitric oxide a little bit. People confuse this with nitrous oxide.
That’s why the dentist uses nitric oxide if you Google Nitric oxide Nobel Prize, you’ll see three scientists in 1998 who won Nobel Prizes for their work on nitric oxide as it relates to cardiovascular. Nitric oxide dilates the blood vessels plus does a whole bunch of other things. So the NOS three enzyme is what makes the nitric oxide that helps with circulation.
Nos to is somewhat related to your immune system that when we’re exposed to the virus, bacteria pathogens parasites, this guy kicks in and makes a lot of nitric oxide to kill. Is that a good thing? Yeah, unless it’s overactive, you’ll hear me say this many times. So this extra histamine can stimulate this. There are two snips in nos two that actually make it overactive. Okay.
And you’ll notice up here it says Carnahan reaction. We actually named this after Dr. Joe Carnahan, who actually had some up regulations of her nos enzymes. So if you’re intrigued with this, again, just go on YouTube, Carnahan. And then I nos I nos. And again, about an hour and a half on this. And that’s just even just touching the surface. But what happens is there’s a substance called BH for tetrahydrobiopterin.
What’s needed to make nitric oxide? Now, we don’t have it on this chart, but there are genetic mutations that can cause you to make less of this. After BH four does its job of donating it turns into BH two, and needs to be recycled. Well, if it’s not recycled, or overused, we run out of BH for BH two is the only thing that’s available. Nos keeps running. And rather than making nitric oxide, we make a free radical called superoxide. And I’m sure people have maybe heard the term Raynaud’s where people’s hands and feet are so cold, that they sometimes turn white or purple.
That is related to not enough of the NOS. INR suppresses Enos so in other words, when their body’s got to an invader to fight, it says, circulation, you got to take a backseat, we got to kill somebody. Again, we need that for protection. But when it’s overactive, we have a problem. Then to add insult to injury, the superoxide combines with nitric oxide to make something called peroxynitrite, which is very damaging, and very inflammatory. And if that’s not bad enough, it further inhibits pH four. And we’re on one merry-go-round here. Dr. Rosen that just creates a problem. How much brain odds do you see in your practice?
Dr. Joel Rosen: I don’t know. It’s probably 50%. It’s part of the symptomatology of cold everywhere. You know, lack of blood flow brain fog? Are you correlating it with all sorts of vascular decreases in blood flow?
Dr. Bob Miller: Absolutely. Yeah, these people also oftentimes get spider veins and varicose veins. Now, not to stimulate or activate your platelets. And this makes your platelets sticky. Well, what happens when that happens? You’re more prone to strokes and clots, which of course right now we’re seeing a tremendous increase in then here we go. We stimulate grantees. That’s what we started talking about grantees.
Now it doesn’t end there. Grantees come over here and stimulate mast cells that stimulate more histamine that stimulates grantees. And we’ve got one merry-go-round going on here, just a feedback loop that just keeps going. And that’s why some people are like, I don’t know what’s wrong, it just seems like you’re getting worse and worse. Now, again, the body is pretty amazing. We all know the benefits of fish oils.
And many people take fish oils, and they’re helpful. And I’m sure you’ll see some people who take fish oils as a quid made me worse why? There are enzymes called fads, fatty acids, and desaturate aces that actually have to take those fats and put them into a form that we can use. And I’m sure if anyone’s ever looked at a bottle of fish oils, they say EPA and DHA, and DHA is the one that’s most inflammatory.
There’s a mutation here that can occur on El OBL to that this last step doesn’t occur. But look at the cofactor. We need NADPH for these guys to work. And I don’t know if I pointed this out. But the KNOX enzyme uses NADPH to make inflammation. So NADPH is a fascinating molecule. It is used to help the fats be useful. It helps recycle your glutathione it does many good things in the body. It’s needed. If you look down here, it’s one of the factors needed for nitric oxide.
But the KNOX enzyme also uses it to make inflammation. So let me say that again. NADPH can be used by some enzymes to be anti-inflammatory. But they can use by the KNOX enzyme to make inflammation, that’s the only molecule I’m aware of, they can play a dual role, reduce inflammation, or make inflammation. Well, if this guy is running all the time, you don’t have enough here to help deal with your fats. You take fish oils, and you feel worse. So that’s why Bob Miller hypothesis. And that’s just it. That overstimulation of NOx is the key thing that’s occurring. And I’m going to show you how that actually occurs in ferroptosis. So I don’t know if you’ve ever heard of many of our listeners ever heard of, like SPM actives. They are fish oils that are processed down to the point where they get these protections, and resolvins. And then that helps with this activation of the platelets. So now I’m going to go over another direction here. Any comments or questions so far?
Dr. Joel Rosen: Yeah, I mean, I personally have I think eight or maybe 13, homozygous FTAs, and so forth. Are you seeing that be very common to Bob?
Dr. Bob Miller: Extremely. And what’s interesting, you know, we have, you know, for those of us who do this work, we’re many times the last person that we see, I mean, people who like for myself as a traditional naturopath, we’re not the first place. I often get referrals from physicians around the world of I don’t know what to do anymore. See if Bob gives any insight, one of the most common things we see is mutations in the fads enzymes because you just cannot make the protections and resolvins to calm it down. So when I see this, I tell people, I have some friends for life for you.
And that would be things like pant Athene choline, a digestive enzyme that has helped break down fats, you can’t fix your genetics, I should have mentioned this in the beginning. At that moment, the sperm and the egg went together. Nine months before you were born, your genetic pattern was made. When you leave this earth, it’s going to be identical.
So if you inherit some of these mutations, you can’t fix it, but you can compensate for it. So these people oftentimes need to take DHA, or protections and resolvins, or some things that help them break down the fats. But also we got to calm down NOx. Now what happens in this TNFA gets upregulated either by genetic mutations, environmental toxins, lack of the tea box, or not being able to hold back extra iron, there’s an enzyme called PLA too. Now this little diagram up here, this little line rather, is your the membrane of your cells.
And there’s something called arachidonic acid that is stored in the cells and plays a good role. It’s not all bad. arachidonic acid isn’t all bad. But when it’s yanked out of the cell membrane, it can go down multiple pathways, it can go down through Cox two and make inflammation. It can go down through Cox one and make something called thromboxane. That can make your blood clotting.
It can go down 12 blocks and we’re going to talk about that. Next, I’m just going to hold that thought where it can go down five blocks and make what is called Luca tries, that can be can be very inflammatory leukotrienes are associated with hearing loss, heart palpitations, arrhythmias, and beginnings of memory loss. So we won’t have time to get into that today but either five locks 12 locks, Cox one, or Cox two.
Now there’s an interesting urine test called urine inflammation that measures the thromboxane a two and probably in most of the people we talked to in our health coach and we have them do a little finger prick test called a mega quant that measures the arachidonic acid, the EPA and the DHA and then looks at the ratios. So look who calms down PLA to recall steroids from the adrenal glands.
Dr. Joel Rosen: Bob, can I ask that question? Sorry, I know I won’t remember because every time you say something so insightful. I come up with another question. So I hope you don’t mind. I’m interrupting. As far as the inflammation test that tests the thromboxane and then you’re doing the mega quant? When you’ve mentioned that you’ll see pathways like us together. Can you tell us about the utility of those two tests when certain values are low in one area and high in the other? How it directs your approach to help with those patients?
Dr. Bob Miller: Very, very good question. What’s interesting is, as I said thromboxane you know makes the blood thick. And actually this this test is sometimes used to see if aspirin has been effective in helping the clotting But what I’ve noticed is again, Bob Miller clinical observation only, okay? But sometimes we’ll see higher arachidonic acid and high thromboxane.
Sometimes we’ll see higher arachidonic acid and low thromboxane. What I’ve been hypothesizing and it’s just that just a theory that when this is high in this isn’t, it’s not going down this pathway and is likely going down one of the others, and just from a clinical observation standpoint, that seems to be correct. So they two go hand in hand. This is called an inflammation test, and some people are freaked out were like, Well, I’m beyond perfectly normal, what’s wrong? Nothing.
I believe that it’s going down other pathways. And there are mutations in the 12 blocks, and I’m gonna get to next that really creates what’s called this Therap ptosis. So here’s your, here’s your adrenal fatigue, your adrenals are just beating the band as hard as they can to make the cortical steroids to calm this down. So what we have to do for this, is there are various nutrients that we won’t we won’t get into today, but there are various nutrients. One example is something called City Choline.
There’s also resveratrol, they calm this down, but you also have to get out of the mold. And I can’t emphasize enough how I believe mycotoxins is is a huge factor for many individuals. Great Plains has a test on mycotoxins in real-time. Dr. Andrew Campbell has a test as well as lots of ways to check for your peer mycotoxins. Then as we make more histamine, as we said, that stimulates the grantees, the mast cells, and here we have yet another feedback loop that just feeds on itself.
So what we want to do now Dr. Rosen is we want to move towards the next pathway, because I believe I covered everything here. So I’m now going to go to something called ferroptosis oxidative damage, which means the cells are being destroyed to the cell membrane leading to cell death, related to iron ion accumulation and lipid that’s your fats peroxidation. And they’re the important markers of oxidative damage. It’s an iron-dependent, nonapoptotic form of cell death that is distinct from apoptosis, pyroptosis, and necrosis.
Now, here is what here are the cliff notes on what happens. And then I’ll show you some of the things associated with it, we’ll take a deep dive. Look who’s here. The Knox enzyme, maybe my drawing tool here, again, is the NOx enzyme. And what it does, is it takes oxygen. We spoke about this earlier NADPH two, called the NADPH DL makes superoxide then an enzyme called superoxide dismutase makes hydrogen peroxide. Then iron combines in what’s called the Fenton reaction, we’ll get into that a little bit more, making what are called hydroxyl radicals. Now remember, I said that a LOX is one particular e lox 12.
That brings your fats down, and it’ll combine with his hydroxyl radical to make what’s called a phospholipid hydroperoxide, which damages the membranes. And I was introduced to this by Dr. Harold Landis, one of the folks who use our software and also on the Webinars, a brilliant gentleman dedicated to the wellness of humanity. And he introduced me to ferroptosis.
And he kept saying to me, Bob, you got to look at this. And I kept saying, Well, yeah, I’m looking at a lot of stuff. And I finally said, How about if you do a webinar on this, and he did, and I’m like, Oh, my goodness, it has just changed the whole game. Because I believe a lot of these chronically ill folks who are exposed to mold or Lyme disease long term, have ferroptosis going on. So here’s the damage, then we need something called glutathione peroxidase for CO q 10. And BH for calming this down.
And also vitamin D, which is now on this chart. So as you can see, this is a 3d chess game, maybe even a little bit more complicated than that, because there are just so many factors that can cause this to occur. Now, let’s take a look at just some of the things associated and I believe we’re just hitting the tip of the iceberg. Many of your nervous systems Alzheimer’s and Parkinson’s, heart failures, osteoporosis, pancreatic issues, kidney issues, gastrointestinal issues or inflammatory bowel diseases, liver issues, lung issues, and eye issues like macular are all related to ferroptosis.
And I think we’re just scratching the surface. This was only first discovered in 2012. So we’re talking about just 11 years ago when this was discovered. So from a historical standpoint, relatively new, in the medical world, so that’s why many people are not talking about it. So now let’s look at this map here. And look at what creates ferroptosis. Now we have it in a different location on the map, but you’re gonna see the players are the same Tnfa that we just spoke about by the toxins virus lab upon lipid polysaccharides. And you’re absolutely right, I need to have more in here than just HFCs or real plasm Ferro important.
Many other things need to go on here, but anything that will stimulate TNF-a stimulates NF kappa B. The bilirubin and Billy Verdun are here just as heme oxygenase but it’s actually those things. As we said, calm this down, calm down to anacrusis factor calm down knocks but the NF kappa B stimulates the knocks. Now there are other things that will stimulate knocks. There’s an enzyme called Colm T. That helps clear dopamine and Colm T will stimulate or the dopamine will stimulate the NOx. We spoke earlier about EMF there’s EMF that affects NOx no matter what.
But there are some people who have mutations in the calcium voltage channel that allows it to even more so stimulate NOx. One of the things that I’m seeing more and more of is there’s an enzyme called su ox that turns sulfites into sulfate. And sulfates are needed in a detox process called sulfation. These sulfites can often stimulate the NOx enzyme. So we got a lot of things here that make the docks overactive. So then we make superoxide.
There’s an enzyme called N q o one that holds this back. Many people have weaknesses on their end Q one. Then here we get hydrogen peroxide. And yes, the same thing you buy in the store is that they put on a cut and hydrogen peroxide. Again, not all bad, it kills pathogens. However, if it’s overactive, we have a problem. Because it’ll combine with iron. Now what we did here is doc rows and you’ll see here we listed all the things TRF to ferritin, light chain, HIV transfer, and factor and we’re finding SLC 48.
One to be significant we found for snips that actually cause very important to be overactive, which causes the body to absorb more iron and distributed it more widely. clinical observation only when people have homozygous on those ones that are overactive, we oftentimes see more, more inflammation inside the body.
Here’s a term probably a lot of people have not heard Thrive Doxon is just as powerful as good a bio that clears hydrogen peroxide and takes care of inflammation inside the cells. clinical observation only week does on this enzyme. Many times people are very inflamed and as we’ve been supporting it seeing a nice improvement in the inflammation. Catalase is needed to clear hydrogen peroxide you can have genetic mutations on catalase glutathione peroxidase, one uses glutathione to clear hydrogen peroxide.
So you can have a lot that can go wrong here. You can be overproducing the hydrogen peroxide. You can have weakness on catalase, thrive toxin, or glutathione peroxidase that you don’t clear it, then you can over absorb the iron hydroxyl radicals. Now before I get down to the ferroptosis Let’s look at glutathione because glutathione peroxidase four is what neutralizes ferroptosis we spoke about Nerf two and kept one earlier. They’re involved with all the genes that make glutathione. So if you have a weakness here, you may not make enough glutathione so here is that a lux 12? Remember we talked about arachidonic acid? So if you’re not dealing with your fats properly, okay? And you’ve got TNF-a an upregulated.
Here comes your arachidonic acid and Dr. Rosen was we’re doing these Omega quants. We’re seeing folks that are actually off the chart on their arachidonic acid. The chart goes to 32 and we’re seeing people in their 40s and 50s. Also cortisol, here’s your adrenals Okay, so the cortisol from the adrenal so you can see the adrenal gland with acid to Koay. And progesterone makes the cortisol calms down this PLA too. So if your adrenals are weak or tuckered out, you’re not going to allow the body to stop pulling out that arachidonic acid that creates this ferroptosis. So you can see the adrenals are highly involved with all of this and their fatigue will add to the problem. So here you make this ferroptosis.
And we just spoke about all the problems that that can create. Now what we want to do is we want to look at how the body can calm that down. BH for now since I’ve heard that before, remember, I talked about that with nitric oxide, pH four is needed to make nitric oxide. And as I said earlier, if we run out of BH for running off pH two, we make superoxide. And people are thinking, Well, does that feedback up here? You betcha it does.
Another feedback. If NASA is overactive from histamine, it’ll stimulate it, and you can have genetic mutations, then that nos to again will create the grantees, but we’re chewing up our BH for there’s also genetic issues that can cause the body to not make enough BH for you can have genetic issues, particularly MTHFR, 1298. So if Nostru is upregulated, you don’t make enough BH four, and you’re making a lot of ferroptosis. You don’t have the ability to hold this back. If you’ve got a weakness in your nerve keep one or make a glutathione peroxidase. You don’t have the ability to hold it back.
Now, I don’t have this on a chart, but BH four is also the cofactor. For tryptophan to go into serotonin. Why are we seeing a huge increase in depression? One of my four famous words is it’s not your fault. Because if you don’t have enough pH four, you’re not going to make serotonin.
It’s like having a brand-new car with no gas. I can’t tell you how many people are just relieved that. Oh, you mean I’m depressed? Because I don’t have enough pH for Yeah. What are you seeing with depression? Dr. Ruden?
Dr. Joel Rosen: Yeah, I mean, all mood disorders, right? I think that because with the BH for and the neurotransmitters and dopamine and adrenaline, you see just the overwhelm the angst, the anxiety, the depression, all of the mood disorders are sort of synonymous with that chronic exhaustion, that presents pretty much all the time.
Dr. Bob Miller: Sure. Now, finally, we’re going to talk about CO Q 10. So co q 10. One people are familiar with this. And CO q 10. is formed in two forms. There’s ubiquinone and Ubiquinol. So what has to happen here, let me get my drawing tool one more time. Here’s your ubiquinone. And then we need this enzyme to turn it into Ubiquinol. And that’s the form that comes down this issue.
But it needs. You’ve heard this before NADPH. And what knocks down the NADPH, the NOx enzyme, also any genetic mutations in here, or on NQF, one will further impede the ubiquinone Ubiquinol conversion. And you can have mutations down here as well, that will impact your body’s ability to make Tokyu Tim, personally, I’ve got one huge mutation on this one.
So I take three to 400 milligrams a day of Ubiquinol. If you look at your co Q 10 supplements, if they don’t say they’re Ubiquinol, they’re probably a big unknown. But if you look at the fine print on the back, it’ll tell you ubiquinone or Ubiquinol. So if you’ve got any trouble here, we’re here or here, or possibly even too much of this, you may need the Ubiquinol version of CO q 10. So as you can see, there are just so many ways here that this ferroptosis can go running wild. And I should also point out that ferroptosis is not all bad. If somebody has a tumor, the body will actually use ferroptosis to kill the tumor.
So again, I think that in the intelligence of the body, this was put there for a purpose to actually kill bad guys. So it’s not all bad. If we didn’t have ferroptosis. If something bad would happen in the body, we actually need this to kill it. So if somebody is inactive in cancer, you don’t want to take the steps to calm this down. But unless you’re there, this can do a lot of damage inside the body. So it’s interesting how something can be harmful, or actually can be can be life-saving, and from what I understand.
There are actually some therapies where they’re trying to use magnets and things to pull ferroptosis to tumors. And actually, Tim rarely increases ferroptosis to ferroptosis, to kill, to kill the tumor. So that is, probably, a two-day lecture in 45 minutes. I just like to mention if anyone’s up a practitioner, health professional, you may want to, you know, consider using our software I know Dr. Rosen uses it, we have our own genetic test, we have a supplement line, the software that analyzes it, we do the research. This is for practitioners only. We have an online certification course where somebody can, can actually take the course and, you know, learn all of this, again, for practitioners. And there’s the website, functional genomic analysis.com.
Again, practitioners only, please, if somebody does want to contact us, here’s our website, and, and phone number. And here’s our support staff for practitioners on the software. So that is a really quick, quick overview of how those two processes, the creation of grantees, and the creation of ferroptosis can really stress the adrenal glands and the entire body.
Dr. Joel Rosen: Thank you so much for sharing, isn’t it amazing to see your last 10 years in about 45 minutes? And you know, it’s all summed up right in there, couple of things I will say is that just as a small plug towards you guys, the staff and the feedback, and the way that you get back to everyone is amazing. And from a practitioner standpoint of view, which I’m looking into more and more now, when you look at the different pathways, and you have uploaded the particular nutrients that are evidence base that support those enzymes.
And you have that built into the software such that when you click on the formulation, it gives smart suggestions as well, you may not need this because they don’t have that particular snip there. This one is suggested. But because there are so many, we suggest that you boost that level up. And that way you can customize the Bob Miller co Q 10 products specifically for your jeans. And it makes it that much more user-friendly.
And it’s a win-win for everyone. Yeah, so so a couple of questions I have, which is amazing that you shared all that is I have started around the word you used as a game changer. And just so you know, I hope you don’t charge me for the patenting of your phrase, but I say to everyone that I work with before I start with them, there is no bad news, right? Because when we look at your genes, like you said, You’re born with them, you’ll die with them, and you can’t change them.
But the great news is, is that we can identify where the challenges are so that we can support that function and be able to impact your overall health. So with that being said, when you look at all those pathways, and you mentioned, it’s a game changer now, in which ways has it been more of a game changer for you now with those two pathways that we talked about? Such that there are so many different places to start? How do you know, what’s the art of you having a clinical observation, you have Bob Miller’s sneaking suspicions?
Do you want to have, quote-unquote, the most bang for your buck? So I guess the question really is, how’s it been a game changer for you? And how has it changed up some of your approaches depending on how aggressive or how much the patient wants to approach the remedy side of the solution?
Dr. Bob Miller: Sure. Well, you know, I’ve been doing this for a long time. You know, in the early days before we had the genetics, if someone was inflamed, you know, we’d say, well, let’s do some turmeric and Boswellia. And, you know, we probably helped some people, we supported the adrenals a little bit. Then as we moved along, we learned about glutathione. And we could see that, you know, maybe glutathione isn’t recycling and then it’s like, okay, we’ve got to recycle your glutathione first.
But now with these recent revelations, we can actually see that it may be gained a function on TNF-a more weakness in HEMA or weakness insert one. So one of the things I like I say, as we’ve got to get away from Oh, this is my protocol because everyone is unique. So when somebody says this is what I do for mycotoxins, it’s probably helpful, but it’s different for everybody. So for one person that’s exposed to mycotoxins, you may need to support the pathway. For other people, you may need to calm down the tumor necrosis factor for other folks, if it’s the NOS, you may just need to start first by calming down nos to or calming down the knocks enzyme. Or if arachidonic acid is being ripped out of the cell membrane.
You may just start there. So you could see you know, 20 people say, for example, all being exposed to mycotoxins and inflamed and you know, 20 different protocols. So to me, that’s the game changer that you going in and finding the most relevant place. And then, you know, one of the challenges is many of these people who are inflamed. You know, they’ll tell you, I can’t take anything. And they’ll take one nutrient and they’ll open the capsule and take little grains of it and still sometimes have a reaction because they’re, they’re so inflamed. So, you know, some people, you can put the proverbial pedal to the metal and hit lots of things. Others it’s like, well, let’s step back here and open this capsule and take grains and see how you do.
And everyone is, everyone is unique. So again, I guess the game-changing part is, we don’t have protocols, we look at where the weakness is. Maybe try to hit the weak spot, weakest spot first. And then as time goes on, you know, every five, six weeks, Okay, where can we go next? What can we do? Because I think one of the things it’s now becoming apparent in the functional medicine with naturopathic medicine than natural health medicine, is that sometimes practitioners get a little too enthused.
They, they see that, oh, you’ve got, you’ve got mold you got, you got clostridia, you’ve got heavy metals, you got some virus, we got to kill or clean or something. And many times that backfires. And then the person gets worse and just throws their hands up and says, I can’t do this. So one of my other favorite expressions is when the house is on fire, we don’t paint the walls and mow the lawn. So many times we have to take baby baby baby steps. Calm down that inflammation, just don’t be in a hurry.
Don’t try to be the hero, right out of the gate, because we’re hearing more of that, that people are like, oh, yeah, I did a test and you’ve got Clostridium, and I’m gonna give you this drug, and stuff to kill it. And the person’s like, I can’t do this, it just made me worse. And then that, that gives functional naturopathic, you know, other kinds of care, a bad name, because they just made them worse.
So another little cliche that I’ve enjoyed is, I’d rather be a little late than too soon, or the fastest way to get there is to go slow. And so I think as we are being exposed to more and more environmental toxins, it’s just unprecedented. And I’ll be honest there, there’s times I worry about, what’s this going to do to humanity. Are we going to? Are we really going to survive this?
Or are we just going to be in a downward spiral here? I’m not saying that’s happening, I that crosses my mind every once in a while that, you know, we’ve done some unintentionally bad things. When people gave animals growth hormones, they probably meant well of, oh, we’re gonna get 10 per 12 to 15% more production, never thinking that that’s going to jack up, the mTOR.
When we came out with plastics, oh, we don’t have to worry about washing the bottles and all those things. But now the waterway is polluted with all these plastics, or the agricultural chemicals, oh, we can have more food production, we can feed the world. But oh, you know, unintended consequences. And I think and cell phones, I mean, we all my goodness, love our cell phones. So you know, I grew up in a world you had to find a phone booth if you wanted to call somebody. So we love it. But we don’t know what the long-term consequences are of continual exposure to electromagnetic fields. So we’re living in some very challenging times.
And you’re seeing everyone getting so angry, so polarized. I’ve never seen a time when people are so angry. One of my favorite stories is when I grew up, I grew up in a little town called Terry Hill, Pennsylvania. And it’ll make your school if somebody would have said, Oh, you need to lock the doors and get guards we would have said, What are you crazy? It never crossed anybody’s mind. And it never happened. It just didn’t happen. So something’s going on with our brains, you know, with autism going up. And everyone’s coming unglued. And I’m sure you’re finding that as well that people are less tolerant and get angry quickly. They’re frustrated. It’s a very challenging time to be alive right now.
Dr. Joel Rosen: Yeah, absolutely. Thank you so much for your words of wisdom. I think it’s you can see how far we’ve come from just MTHFR I don’t think you mentioned it well, maybe just in making by Opteron. But we’ve come so far from that. And I think it’s really putting your thinking cap on in terms of what when people say, well, genetics, what is genetics have to do with it? You’re seeing sort of the blueprint of how the environmental factors impact your body’s cellular ability to make energy effectively.
And if there are these roadblocks and 3d chess game played underwater inhibitors, promoters, everything in between, it’s really going to make an impact. So I guess you really have to use your doctor’s hat and terms of okay, if we need to go very slow, what is going to have that Pareto principle of the least involvement for the most gain? And slowly building from there? A couple of things that I’ve also maybe if we can just share and if it would be okay, is some of the successes that you might have had with when you do see that, that platelet activation and the Pharaohptosis.
Dr. Joel Rosen: Ferroptosis? Sorry, yeah, that you’ve been using sort of a combination. And again, this is just for informational purposes. You’ve been using a combination of the CO Q 10 at small amounts with royal jelly and potentially hydrogen. I guess it’s hydrogen water. Have you been noticing some really slow but great effects through that, Bob? Are there other combinations of things that you’re doing?
Dr. Bob Miller: Yeah. And sometimes they’re slow. And sometimes they’re dramatic. I just had a client that was so excited to tell me Oh, my God, Bobby, this CO q 10, I’m awake, I have energy. And not everybody experiences that, you know, you just mentioned MTHFR. And I really would be remiss if I didn’t address that a little bit. You know, 15 or so years ago, we learned about MTHFR. And most people know that when you’ve got that genetic mutation, you may not put a methyl group on your, on your full lead very well. And that can impact a process called methylation.
Really important. I’ve you know, I teach about methylation, I actually formulated a product for methylation. But I think we’re getting a little too enthused about that, for two reasons. One, you know, pregnant women need Foley. And the reason they need folate is because there’s a process called mTOR, that causes the cells to grow. If we didn’t have that we either wouldn’t get pregnant could have a miscarriage, or, or a miss, or a deformed baby.
So mTOR is very important in pregnancy. But mTOR is also what allows the body to replicate things. It’s like a copy machine. And it doesn’t care what you put on the copy machine, healthy cell cancer cell, or even some viruses that we’ve recently been dealing with. So we got to be careful that we don’t overdo that plus, in addition, there’s an enzyme called histone and methyl transferase, that takes histamine and turns it into something called N methyl histamine.
And that has to be cleared further down the road. Methyl folate, methyl v 12. And Sammy will stimulate them. So some people, you know, they’ve learned they have MTHFR. And I’ve seen this happen. I mean, I just recently had a young lady who was taking 15 milligrams of methyl Foley daily and was incredibly inflamed and sick. And it’s like, yeah, no wonder.
So if you’re not pregnant, or you’re not specifically working on homocysteine, or something else, we’ve got to be careful with methyl folate and, and too many people just you know, they get a home test and they learn they have MTHFR, they look it up, they start taking a lot of methyl folate, and they don’t realize that some of their anxiety and inflammation could because they’re getting too much of it. When I taught classes on methylation, my opening slide was a mother duck with ducklings behind her with the title, make sure you have your ducks in a row before you start supporting methylation.
So if you’ve got a histamine problem, or a dopamine problem, too much methyl folate could actually be a problem. Now, again, if you’ve got high Homocysteine if you’re pregnant, I mean, there are times we need it, but I believe we’ve gotten a little carried away with methyl folate. So I put that out there that when you look at the pyramid that I created, the last step is supporting methylation.
And I believe we’ve gotten just a wee bit carried away on that all-well intention, nobody meant anything harmful because everything you heard about methylation is true. But again, back to unintended consequences. Right? And jack up the mTOR can jack up the histamine and be more trouble than it’s helpful.
Dr. Joel Rosen: Right and stimulate Knox enzyme as well. Right? We already have enough thing stimulating knocks we don’t need it stimulated anymore. Yes. So just as the other thing I was gonna mention is to have you fine with these game changers because the pyramid was really designed for at the top is methylation at the bottom are inflammatory stimulators that and you’re looking at it as getting your ducks in a row is another way of saying well, let’s reduce the overhead Let’s reduce the that’s the house is on fire.
Let’s put out the fires before we start mowing the grass and painting the walls. Have you found that that pyramid is changing now because of all of the rent sees rent Auntie’s pathways and ferroptosis paths weigh in a sense that certain variables now need to be looked at in a 3d motion versus a pyramid kind of way or
Dr. Bob Miller: I Think the pyramid still applies, because you know, the bottom left-hand corner is iron dysregulation. And that’s what, that’s what ferroptosis is, right? The Knox enzyme is, on the bottom row. Right? So and it still interplays with your ability, to make your antioxidants, your glutathione, your catalase. What I’ve been finding is that now that we’ve, you know, increased, the function of the maps that we actually have in there, I mean, I was just showing you static pictures here.
But in our software, we actually have interactive maps where you can click on the enzyme, and I didn’t use that today, because it might be harder to see that you can actually click on the enzyme and see where it is. But the principle hasn’t much changed since knocking down inflammation first, but we just nuanced it, possibly a bit more.
Dr. Joel Rosen: Now, it’s become a lot more sophisticated. You’ve always said, Hey, listen, this is a general idea of where to start. But if you see some more specific, perfect storm challenges in the middle of the of map, be the clinician and do the appropriate approach.
Dr. Bob Miller: So you did a good point that you made a good point, you really do have to be the clinician, you can’t have software until you have every move to make, the doctor still has to be the or the naturopath, whoever it still has to do their job and think it through no matter what tool you have, it’s not going to answer every question for you.
Dr. Joel Rosen: Right. And so and then also, because I know you do lots of case studies, and a lot of these people are really, really having a hard time. And like we say when you do a consultation, there is no bad news. When you do put these puzzle pieces together and go slowly, Bob, maybe you could tell us a little bit about some of the successes that you’re seeing for patients that have been to every doctor and haven’t had any improvements and how the body infinitely and its intelligence has the ability to heal. Maybe give us some hope to the listeners that they think oh, my goodness, this is just too daunting.
Dr. Bob Miller: Yep. Well, firstly, I tell everybody, there’s, there’s no magic cure. You know, there’s no, take this one pill, and in two days, you’ll be better that doesn’t exist. So it’s, it’s a journey, and it’s not for the faint of heart. And it may mean you know, you know, for some people, we see genetic issues where they may not deal with gluten, and they need to stop gluten.
And for some people, that’s a no-brainer, hey, if that’s gonna help me feel better, that’s good. For other people, you think it was the most traumatic thing you’ve ever told them. And they can’t handle that they can’t eat, they’re gluten. For some people, it’s less histamine. For some people, it’s turn off the Wi-Fi at night. For other people, it’s, you know, some dietary changes with dairy. And it’s, you know, we’ve generally seen when people stick with it for a period of time, have realistic expectations, you know, not miracles, and not the, you know, somebody says, Hey, I started on the supplements three days ago, and I don’t feel any better. It’s like, Yeah, no kidding.
It’s a journey.
And, some people are willing to take that journey, and some people aren’t. And you know, I, I’ve learned a long time ago not to argue with people if they don’t want to go on a journey. But the bottom line is for people who will stick with it, that I mean, the bottom line is less inflammation, more energy, better sleeping, less anxiety, and less depressive thoughts. And again, we’re not treating any disease because the body is coming into balance. On its own, we don’t, somebody says, What do you treat with this, we don’t treat anything in the body comes back into balance.
When you create that terrain that’s friendly. This goes back to the old, old old naturopathic philosophy of, you know, it’s the terrain, Antoine Muschamp said that it’s the terrain of the body that allows things to arrive. We’ve kind of got in the thought that we’re going to have a magic pill that’s going to suppress the symptom. That did work for a little while. But I think things are now getting more complex because of all the environmental factors that those days of a magic bullet are, are going away very quickly. So that’s generally what we see less inflammation, more energy, more mental clarity. But it’s not easy. It’s not quick, not for the faint of heart.
Dr. Joel Rosen: Right. But when they’re finally getting some answers, you know, especially when they haven’t when they’ve been told that there’s quote unquote, nothing wrong, or there’s nothing more I can do. Have you found that the Omega Quant has been a game-changer as well?
Dr. Bob Miller: for you. Oh, yeah. I am stunned how many people will do the Omega Quan and they’re off the charts. I mean, that they have a charting of where it goes and it’s, you know, like the top I think is 32. And there are people that are 45 to 70. And those are the people that that arachidonic acid is being yanked out and they had no idea that was going on.
And you know, from a disease standpoint, that’s not a disease. You know, arachidonic acid being pulled out of the cell membrane doesn’t have a disease name. Now, we’re so used to that concept of, I need a disease name. I don’t, you know, maybe someday somebody will name it. But to my knowledge, there isn’t one. ferroptosis really isn’t a disease. To my knowledge.
It’s a process that occurs. You know, Randy’s isn’t a disease, it’s a, it’s a molecule going arrive. So I think what’s happened is, you know, 75 years ago, you know, most of the things we had were bacterial infections and an antibiotic fix you up, and there you go, or somebody’s part went bad, we cut it out. But we’re going into uncharted territory, again, not because our genetics have changed. But because our environment has changed. I’m absolutely going to tell my clients, as I said, I’m absolutely convinced I look at the genetic patterns of autistic kids.
And I look at myself, and it’s like, oh if I was a 10-year-old boy, I’d probably be a headbang and autistic mess. But he eats there, I think drawing circles is fun. But, and that’s why I think we’re seeing such a dramatic increase in these things. Because, you know, when I was in my mother’s womb, there were no electromagnetic fields. drank out of a glass. I remember as a kid to my parents going to a farmer’s market to buy food directly from the farmers. I’d slop around in the creeks and climb the trees. Now the kids are on their computers and are pushing buttons. And they’re sitting in a school where the food is all processed. And they’ve got everybody’s got cell phones, and they’ve got iPads, they’ve got Wi-Fi in the ceilings.
And you know what, when I talk to teachers, and I say, How long have you been teaching at least five years? And they’ll say, Yeah, five years, and what’s happened to the kids in the last five years, and every one of them says, Oh, my goodness, they can’t focus, they’re agitated.
They’re, they’re struggling. And so these kids that were born into this, when in their mother’s womb, they were getting high fructose corn syrup, glyphosate, and electromagnetic fields and plastics. I believe it’s having a detrimental effect on us. Yeah. And again, if you’ve got a genetic weakness that wouldn’t have mattered 75 to 100 years ago, get exposed to this. These are the potential, you know, the proverbial canary in the mines that are being impacted.
Dr. Joel Rosen: Right. Well, have you found just as my theory as well is, that these gene snips that got passed down that were evolutionary, evolutionary favorable? Because of the environmental inhibitors or the environmental overlap errs are now evolutionary not favorable, is that seem to be?
Dr. Bob Miller: Yeah, there are two theories on how these genetic mutations occurred. One is that during the 1200s when everyone was promiscuous, and I shouldn’t everyone when a lot of people were and STDs were rapid, some of these mutations occur that just weren’t beneficial. But there are beneficial genes, like for example, if you talk to people from England or Ireland, many, many times they over absorb iron. Well, for the Irish, the reason many of them emigrated, was because they had potato famines. So during potato famines, if you over-absorbed iron, that was actually to your advantage, and you were more likely to have a healthy pregnancy.
So that became a beneficial genetic mutation. So natural selection in Northern Africa, and in other parts of the world. There’s an enzyme called G six PD that makes your NADPH I don’t know the mechanism. But supposedly this G six PD mutation protected you from malaria or didn’t allow you to get sick from it. So by natural selection that occurred, when that time, we didn’t have as much inflammation, so a little bit less NADPH didn’t make any difference.
Now, today, since NADPH, is being used by NOx and as needed to recycle glutathione make your nitric oxide, that GCPD deficiency is to your disadvantage. Now, clinical observation, only Bob Miller talking to people, when one parent has the iron over absorption and the other parent has the GCSB deficiency. Those children are oftentimes really struggling, or if you were the result of that. So again, you know, when you look at the history of the world, there wasn’t there was never a time that we were as mobile. I mean, you grew up in a country and that’s why they develop their own languages.
And we don’t know how many 1000s of years they were there. And they adapted to their environment. And now we have you know, travel and everyone’s going in different directions. So the people that have that GCPD mutation, when they’re exposed to things that may use up more of it or are more needed for it, they’re in more trouble.
When when you are when you know that over absorption of iron, and you might be thinking You’re doing a good thing by taking a multivitamin with iron, or eating a lot of meat or something like that it’s actually to your disadvantage. So it’s a complex subject, but that’s why some genetic mutations are just not helpful at all. And we think those occurred during the 1200s when STDs and actually all that when people were riddled with essentially transmitted diseases just damage some of the genes. Right?
Dr. Joel Rosen: Yeah. Amazing to see. Bob, thank you so much for your time. I hopefully can keep it open for part four when we have new information in here. So we’ll be glad to be here. Yeah. And I appreciate everything that you do and and the time and energy you put into helping the world and helping your community and your patient base. Thank you so much for everything you do.
Dr. Bob Miller: It’s been a pleasure and thank you for the opportunity. Thank you.