The Adrenal Thyroid Connection with Dr. Anshul Gupta M.D.


Dr. Joel Rosen: Right. Hello, everyone and welcome back to another edition of your adrenal fixed Podcast, where my mission is, to tell the truth about adrenal fatigue to exhausted and burnt out adults so that they can get their health back quickly. And I’m really excited to introduce my next guest, Dr. Anshul Gupta. He’s a Board-certified family medicine physician with advanced certification and functional medicine, peptide therapy, and is also a trained fellow in integrative medicine. He’s worked at the prestigious Cleveland Clinic department of functional medicine alongside Dr. Mark Hyman. And really now he specializes in treating Hashimoto disease and helps people reverse their unresolved symptoms of thyroid dysfunction. So Dr. Gupta, thank you so much for being here today.


Dr. Anshul Gupta: Yeah, my pleasure. Thank you for having me on the show.


Dr. Joel Rosen: Yeah, absolutely. So listen, I always like to get an idea on your own story, because I have clients or an audience that are exhausted, that are burnt out, that aren’t handling their stress very well, that crash in the middle of the day, they don’t have focus, they don’t have concentration, they don’t have a libido. They don’t sleep, they don’t wake up juveniles. And ultimately, I like to get your spin like a traditionally trained doctor on why that’s happening, and how that’s related to the thyroid and the adrenals. And a different way to think about things and the connection between the two. And we’ll get into that. But why don’t you tell us your own story, why you became a doctor, and if you had any health challenges, so that we can get a little bit of an understanding of how you got to where you got to?


Dr. Anshul Gupta:  Yeah, absolutely. So like I always say is that people who enter the field of functional medicine, almost everybody has their own personal health story or a family health story. So mine was more personal. So as you said, you know, I’m a trained family physician, so I got trained into the conventional side of the medicine. And then I started working in the rural Virginia area. So there, you know, I started my family practice job, a couple of years into the job, I started having more health issues. So I started feeling fatigued, you know, I was having brain fog, I was having stomach issues. And I was, I was gaining more weight. Well, I was always a chubby kid, you know, as a child, but you know, that was cute, and everybody loved it. So I never bothered, you know, like about it. And as I kind of, you know, grew older, again, you know, even in conventional medicine, nobody kind of paid any attention to the weight. They said, Oh, yeah, you are slightly overweight, that’s pretty much it, you know, like, don’t worry about it. Maybe, you know, like, once you get older, you know, you need to figure something out. But now, you know, like, my health was crashing, I was so fatigued by the end of the day that, you know, I was just literally in the evening, I was done. And I would just go to sleep, and I will sleep for 10 hours sometimes. And still, I will feel that okay, well, I can catch up more. And then, you know, like, I was having this horrible stomach pain, nobody knew what to do with it. You know, I was a physician myself.


So I thought, well, I’ll start treating myself. So I started giving some medications, but it was not working. The pain was so horrible at times that you know, I literally thought that I will need to go to the emergency room. But you know, with my training, I knew the emergency room, doctors can only give me pain medications. That’s it because I did not have any other, you know, like significant symptoms. Well, after a couple of months, well, it was not getting better. So I was thought, Well, I’m not smart enough. Maybe my other colleagues are smarter than me. So let me go to all these specialists. So I went to specialist after specialist and then they kept on throwing things at me by doing endoscopy, ultrasounds, and all these different investigations. They keep on adding more and more medications. But in the end, I was still that same miserable person, I was still, I was still fatigued, I was still having stomach pain, I was gaining more weight. And nobody knew what to do with me. And I was just 32 at the time. So I was really scared. You know, at the time, I was like, I don’t know what to do, you know, like, will I be this miserable person, the rest of my life, taking medications and feeling this way. And at that moment, you know, like, there was this moment in my life, I was really scared and without hope, I was like, really, I don’t have a choice. I don’t know what to do. So when somebody actually introduced me to functional medicine and said, You know, like, why don’t you look into that. So I started looking into functional medicine. And like, what I kind of realized was that every person in functional medicine was talking something similar to what I had. And now everybody could relate to you know what I was going through. So I was like, Okay, this is the place I need to be in because seems like these guys have an answer for me. So I started training into functional medicine and I started applying the principles. within one month, my pain was gone, my stomach pain was gone. And within six months, I was off all medications. I was down 40 pounds, you know had more energy than I had ever in my life. So that was a game-changer for me. I was like wow this is crazy like without any medications without A few things, you know, like lifestyle changes and some supplements and things. This is huge. That was like I need to, you know, like kind of, you know, share with my clients, you know, I need to share with my patients, because you know, this is nobody’s talking about it. And so many of my patients had similar issues as mine. But again, I was because I didn’t know what to do, I just kind of kept referring them to one physician or one specialist to another. So that’s where I started to kind of thinking about functional medicine. And I started working as a functional medicine physician. But then, later on, I was working at the Cleveland Clinic center of functional medicine. And then out there, I started seeing a similar trend for some patients who had similar issues in mind. And all of them had Hashimoto’s. And all of them were tired, all of them had brain fog, all of them have weight issues, and they were all on medications, but they had no hope, they will still continue to suffer. So I would like oh, something similar to mine, I was in the same boat as these people. So I can completely relate to them. So I need to kind of do something about them. That’s where I started researching more about Hashimoto’s and started making a protocol. And then I started applying it and I saw phenomenal results. All of these clients, like all of my patients were getting so much better, you know like the fatigue was gone, you know, like the brain fog was gone, they were able to lose weight. So that’s where you’re like, now my passion is there to use this protocol to help as many, you know, Hashimoto’s and thyroid patients as I can.


Dr. Joel Rosen: Yeah, well, listen, that’s an interesting story. And sure, thank you so much for sharing it. I think that once we’ve been through and identify what our clients or patients have gone through, we become a better teacher or doctor, we have more empathy. We don’t necessarily feel that just because the traditional approach is unable to identify objectively what may be going on doesn’t mean that there isn’t something going on. And we talked a little bit before we got started here is the name of my website is called the truth about adrenal fatigue. My mission is, to tell the truth about adrenal fatigue. And I know that it’s a very controversial subject, especially with the allopathic traditional approach and how it’s defined. So why don’t you give us your insight as to what exactly is adrenal fatigue? As a diagnosis? Is it real or how other ways we maybe want to think about that in terms of what it is? I know, it’s a vast question, but what’s your what’s, what’s your, your training and your opinion of what Adrenal Fatigue is, and what may be a better way to define what’s going on?


Dr. Anshul Gupta: Yeah, absolutely. So you know, like, since vino being a functional medicine physician, you know, have been very, very fascinated with this, you know, adrenal glands, right, because we know so little about them, you know, like we only know about the dreadful, you know, like, issues with the adrenal gland where people have this Addison’s disease or Cushing syndrome, whether they have either too much of the adrenal hormone or very little bit of the adrenal hormone, but I feel those are like two extremes. Right, you know, adrenal fatigue lies somewhere in the middle, is a conventional medicine is missing the point that you know, like, there are so many patients who lie in the middle and not on the extremes. And those are the patients who we see on an everyday basis, you know, who come to us saying that, okay, well, I’m Doctor, I’m fatigued, and I don’t know what I’m fatigued, you know, right. And then we check all the adrenal hormones, but these are so-called in the normal ranges on ranges, which we defined, right. But, you know, like, they are still having symptoms, so we missed the point. So for me, Adrenal Fatigue is that if a patient is fatigued or not feeling great, doesn’t have energy, he or she definitely has adrenal dysfunction. Right, sir, the adrenal glands are not functioning optimally as they should be. And that’s where we need to focus on. Now the good part is that now with the new technologies, we have new testing available, which is a little bit better in checking those adrenal hormones, right. You know, the typical adrenal fatigue happens because of the cortisol hormone. So now we have the salivary cortisol testing, where instead of just checking one point cortisol test, we check it out for different points, right. So that gives us a nice curve, that gives us a good idea about what is happening with those adrenal glands on the whole day. Right? Because people you know, like when I was traditionally trained, what I will do is I will check the cortisol levels just in the morning, right? And that will be perfectly fine. But I don’t know what is happening during the day, right? Because most people who have these adrenal fatigue, they have this crash later on in the day, right? That they do not feel great. And but we are not checking the cortisol levels at the time. So we do not know what the levels are with these new testing. I think they give us a good curve, but a good idea. What is happening with their adrenal during the whole day, and I think that helps a lot in the diagnosis of so-called adrenal fatigue. So I think that’s what is happening. And that’s where I call it more as adrenal dysfunction, rather than like an adrenal disease. And then that’s with the way I approach my, my clients, we know who comes with fatigue and who, you know, have this adrenal dysfunction.

Dr. Joel Rosen: Yeah, no, it’s really refreshing to hear. And I do like the idea of somewhere in between, there’s a really good reference paper by Dr. Robert Navio. And he talks about the cell danger response, he has a second follow up paper that talks about the healing cycle. And I did a lecture on that in the environmental and mold conference not too long ago. And what I talked about Dr. Gupta is and what he talks about in that reference paper, and I will post that reference paper and the link for those that want to know more about that is he talks about the need for in the medical approach is to define or write the second book of medicine. The first book is the acute based approach. And the second book is more of the chronic based approach. Because we do go through a healing cycle, where if it doesn’t go from point A to point B, to point C to point D, and it gets locked up somewhere, it’s gonna manifest as incomplete healing and fatigue. And it’s not a reductionistic pharmaceutical-based approach, as much as just take this or take that. So I would say it’s not only better significant tests that we have available that are more sensitive, but it’s also a new paradigm as to how we look at what’s going on physiologically in the body. And one thing you mentioned to me earlier, is that you work with clients with Hashimoto’s, and that has more of a mitochondrial based problem. So can you explain what that actually means? And why that’s important for people that may now realize, okay, it’s a dysfunction of the adrenal glands. It may neither below or neither be high. And somewhere in the middle, there’s probably a new paradigm to define what’s going on at the body. But what does this mitochondrial fatigue mean for me? And what is that? Yeah,


Dr. Anshul Gupta: so like, just to kind of define mitochondria first, right? You know, most of us just know mitochondria is the powerhouse of our cell, right? Basically, what it means is that it is responsible for producing energy, right, you know, our body needs the energy to function. And that’s what mitochondria do. But now over the course of years, we know that mitochondria have a much bigger play role in our body as just you know, as compared to just producing energy. Now, they control inflammation, they are regulators of autoimmune diseases, they control our immune function, they control our aging process. So all of those things, you know, along with energy production, we already know that mitochondria play a role. But now a major role is an autoimmune disease and Hashimoto’s is an autoimmune disease that we know about. In typically Hashimoto’s, what we thought was that the antibodies that our body is producing are just destroying the thyroid gland. So if we give them thyroid hormone that will fix the issue. But in reality, what is happening is that these antibodies are not only destroying the thyroid gland, they’re also destroying the mitochondria. So all of those symptoms, which actually are feeding with Hashimoto’s, are because of mitochondrial dysfunction. You know, we know that you know, fatigue is a symptom of mitochondrial dysfunction. We know brain fog is a symptom of mitochondrial dysfunction. Hair loss is also connected with mitochondria. Obesity is connected now with mitochondria. So each and every you know, a symptom that is there with Hashimoto’s is actually because of mitochondrial dysfunction, but we will totally neglecting it, we thought, okay, it is because of the thyroid, so let’s give them thyroid hormone. And that will fix the issue. But in reality that is not doing it. So that’s where, you know, we need to start focusing on mitochondrial health in Hashimoto’s patients, so for them to get better with it. And then that’s the only way we can resolve all of the symptoms which are associated with it.

Dr. Joel Rosen: Yeah, that’s a great answer. But I think also what’s needed is just like, there’s black and white and not very many shades of grey in the assessment of the adrenal glands, either too high or too low. It’s kind of the same thing with the mitochondria. Tell us about like the traditional approach, when you tell an allopathic trained doctor that may not necessarily be in the functional medicine world, what they think of as a mitochondrial problem they typically think of as a major debilitating illness that doesn’t have a long lifespan. What what’s the traditional approach to what mitochondrial dysfunction is?

Dr. Anshul Gupta:
Yeah, you’re absolutely correct. You know, like the traditional you know, doctor’s offices, still do not recognize, like, you know, mitochondrial dysfunction, you know, like, there are certain mitochondrial diseases, but those are very, very rare. And those are very, very severe, as you said, For a mitochondrial disease to happen, people are basically, you know, like bedridden, or they have these dreadful symptoms that, you know, their lifespan is not much, right. So they do not think that they can even reach adulthood, right? These are all childhood diseases, people might make it to there, you know, like teens or like, you know, to middle-aged adults, that’s it. But now, we are recognizing that you know, with the new research that there is somewhere again, in the middle, where a lot of these diseases have mitochondrial dysfunction. Now, the problem is that we do not still have a perfect test to check for mitochondrial dysfunction. So again, with you know, being an allopathic physician, if somebody says, Okay, well, how do I check for it, you know, like, there is no perfect test for it. So that’s what we are lacking. And that’s where I think the new research is coming up, to kind of find ways to check mitochondrial dysfunction. And actually, there is a lot of new research coming up, you know, with the pharmaceutical industry, of targeting mitochondria and different autoimmune diseases and even in cancer. So they’re already working on it, with, you know, therapeutic potentials for it. And then on the other hand, first, we need to have a test, you know, which, you know, is widely available, anybody can use it, to kind of check for it.

Dr. Joel Rosen: Yeah, no, it’s a great answer. I had an interview with an authority on nitric oxide, and talked about the importance of nitric oxide for mitochondrial health. And then I think like, like any good functional medicine practitioner, they put all the puzzle pieces together the history, the objective laboratories, and the ability to understand the role of environment and mindset to get an overall clinical picture. So I want to switch it up, because one of the things that we agreed to talk to which I think would be very valuable, is really understanding the difference between even though it’s at the fundamental level mitochondria that’s being impacted from the stress response from the environment, from life from exposures from everything else in between. Can you tell me what you how you look at and discern the difference between if it’s a thyroid problem, or if it’s an adrenal problem? Why don’t you tell us a little bit about your insights on that? Dr. Gupta?

Dr. Anshul Gupta: Yeah, absolutely. You know, so, that’s a big question that comes to me a lot of times you know, like, because of these you know, Hashimoto’s attire or clients I see every day right now is that the fatigue that they are experiencing is because of the thyroid issues or it is because of the adrenal issues.

First of all, you know, like, they are all connected right, you know, like, because functional medicine you know, like, we are not just different pieces, right, you know, we are all our organ systems are connected to each other. So, same as with thyroid and adrenal glands, that they have a strong connection with each other. So, one is not working properly, the other does get affected. But a lot of times, you know, like, we can certain times we can differentiate whether the major problem is because of the thyroid gland, or the major problem is because of the adrenal gland. So, some ways you can differentiate is that the first thing you know, as we can see that the people you know, who have adrenal fatigue, these are the people which we call as wired and tired, okay, that these have, like, you know, anxiety issues, and they are always like in the hyper mode, they’re always wired. But then, at the same time, they’re also all the time tired, that this cannot function. Why the thyroid people, you know, if you have tired fatigue, most of these people have like low energy and they feel like low mood like they have more depression issues and things. So that’s one differentiating factor that’s very, very important I see all the time.

Now, the second issue that I see with you know, the difference is the fatigue, the thyroid fatigue, you know, generally happens again, like later in the day, or is there for an only certain amount of time, when most people with adrenal fatigue, they are fatigued all the time. Like they say that when we wake up in the morning, we just feel tired. And like my midday, we’re just done like, you know, there is nothing else that we can do in the day. So those are the people like you know, they wake up tired and then they are tired during the day and the night. So the sleep and all those things will help them out. But they just feel tired all the time. Well tired patients, they feel okay during the morning. And as the day goes on, you know, the fatigue happens either later afternoon or in the evening time.

The third thing is the skin. So what happens is that you know, in the thyroid, the skin is very, very dry. So we see typical dry skin in thyroid patients, while people who have adrenal dysfunction. This career is very, very fragile. Like most people who come and tell me that you know, like I just hit you know, like a knob or a door or just brush you know, like through a table and my skin will break, you know, like so it’s very, very thin and fragile and they are these are young people, you know, like we see this happening like later on.

Like in the 70s, and 80s, but not and people will like 40s, right. So that’s the difference between thyroid and adrenal glands, where adrenal will have fragile skin, well, the thyroid will have more dry skin, but not very, very fragile. And the last difference is weight. So most people who have adrenal dysfunction will have this weight, which is centered around their waist like they have this, you know, they will say that you know, my, all my weight is around my waist, which is I’m not able to lose it. Well, we’re thyroid patients, the weight, you know, is more so in generalized all over the body, more so in their thighs, and buttocks and all those places. So that’s all the differences that you know, have seen over the course of time in my practice, that’s the way I can differentiate sometimes, like where it is retired and where it is actually adrenal glands, which is causing the issue.


Dr. Joel Rosen: Okay, excellent, very, very good information for sure. And like you said, There always is the connection between the two, in that they’re regulated with the same mechanism in the brain that will ultimately cross-talk between each other. And ultimately getting to the root of the problem, whether it’s a thyroid presentation or adrenal presentation is always the goal. But with that being said, let’s say someone comes in and you do your workup, Dr. Gupta, and you find that they’re more of an adrenal based client or more of a thyroid based condition, and your goal is to get to the root cause of the problem and address that, but at the supporting level, while you’re working to work upstream to help them How would your treatment approach differ between the two.

Dr. Anshul Gupta:
So, the way you know like I will approach if it is like more of a thyroid client, then we will start with fixing a lot of their thyroid issues. First, you know, like, obviously, the root is you know, like, we need to figure out the root right, whether it is as you said, whether it is a toxin, whether it is stress, you know, whether it is their inflammation, whether it is infections, you know, like you name it, right, we need to figure that out. But initially, these people are so much suffering that we need to give them some hope. So, that hope differs from person to person. So, if it is a thyroid client, I will start with more supplements, which will be supporting the thyroid, which will be you know, like the selenium, the zinc, the vitamin D, the magnesium, you know, like all of those supplements and then food which are high in protein. So, all of those things, you know, definitely get on board for these, you know, like people with thyroid clients. Now, if they have adrenal dysfunction, those are really difficult to treat, you know, from the get-go. So then, you know, for those people, I will start, you know, with a lot of lifestyle changes, especially focusing on the stress, because definitely, stress plays a huge, huge role in adrenal dysfunction. So, I definitely want to get to the issue, what, why, why are they stressed out, and then start making small lifestyle changes, you know, just kind of taking a few minutes of deep breathing, or like, kind of introducing to the practice of meditation, or like journaling, like just simple steps, which, you know, they can follow along. And then the second of all, you know, I use supplements to support adrenal glands, which is like adaptogens. So those are my favorite things, you know, like, I recommend to a lot of my clients, you know, like, ashwagandha is one of my favorite ones, like Jen, saying, Rhodiola, so those are all great ones, you know, like, adaptogens that I use in my practice a lot, especially people who have adrenal dysfunction. So that’s where I combine the lifestyle of working on the stress management, with these adaptogens for my adrenal folks, while with the thyroid, folks, definitely we work on the lifestyle, but a lot of times we start with, you know, fixing their thyroid gland with the supplements, which are more focused towards the thyroid, you know, and that’s, that’s kind of the difference that I will say, I will start with the approach.

Dr. Joel Rosen: Right, okay. That’s a great answer, well, looking upstream and seeing what is is initiating either or both right and yeah, so Okay. The other thing I was really interested in Dr. Gupta is you mentioned you do peptide therapy as well. So, why don’t you tell us what is peptide therapy and what are some of the applications beyond focusing on the root cause and then supporting specific adrenal and thyroid protocols is how do peptides fit in?

Dr. Anshul Gupta:
Yeah, absolutely. So, peptide therapy is actually an emerging new therapies that you know, we are kind of, you know, knowing more about, so, what are peptides So, peptides are actually natural chemicals, which our body produces all the time. So, now, we know what amino acids right So, basically, peptides are a very, very small collection of amino acids, which you know, like have signaling potential. Now, people will say, Okay, well are peptides proteins, so I say, well, they are a little bit different. Proteins are definitely a collection of amino acids, but those are a collection of long chains of amino No acids, while peptides are very, very small kind of, you know, chains of amino acids, which does a lot of work, which is basically signaling work, like so basically, they signal the cell to perform different activities. So they a lot of times they control inflammation, you know, a lot of times they kind of control how our body responds to like external environment, they control immunity in our body and a whole bunch of things. So, the oldest peptide that we know about is insulin. So insulin is actually a peptide. So in the 1960s, is you know, the first time where we were able to produce insulin. And that’s the first peptide that you know, got introduced to and almost everybody you know, you know, like knows about insulin now. So the issue with peptides at why we were not able to produce more peptides into more therapeutic potential was that we were not able to make them stable right. So, we know about peptides which are present in our body, but we are not able to produce peptides outside of our body, because they were not stable. But over the course of years, with new technology coming in now, the peptides are big, we have we can make them more stable like shelf-stable. And the second problem was that as soon as we will consume those peptides, the body will break them down, you know, our bodies enzymes, our body’s defense mechanism will break them down. So, they were not able to do the job. But now again, with new technology, what we can do is that we can combine them or we can you know, like manufacture them in a certain way, where the body you know, they can survive in the body and they can do their job.

Dr. Anshul Gupta:
So, the now, the peptide therapy, when it comes when it when actually started off, people were using a lot of these peptides for basically like weight loss and also especially for building muscles. So, growth hormone was the most common peptide that was initially introduced, it was called anti-aging, it was called you know, like about like gaining muscle mass and all that stuff, but it has a lot of like side effects and potential you know, with you know, like causing issues or problems with people. So, then that way, you know, now we have safer peptides, which has more wide potential. So, now, again, the fitness industry is the number one industry which still uses these peptides, you know, like, which has which are like not growth hormone, but now, these are like growth hormone secretagogues, which basically helps to secrete the growth hormone, but these are not directly growth hormone. So, these are some of them are like cjC and EPA modeling, those are the most common ones which are used in the fitness industry, which helps with weight loss and also kind of help with, as I said, anti-aging potential, you know, helps with sleeping and all that stuff. The other peptides that we’re using one is called BPC, so, that is a healing peptide, so helps with healing a lot. So it helps with wound healing, you know, it works, what healing in your GI tract. So, a lot of people who have leaky gut, you know, or people have, you know, like gut issues, you know, we use BPC a lot. The other class of peptides you know are called thymosin Alpha one. So, this is the peptide which regulates your immune function. So, this is a peptide you know, which has been useful for autoimmune diseases or lowering inflammation, and then it has actually also, it has some antimicrobial properties too. So, there are some research studies which you know, show that it can be helpful for hepatitis patients. So, this will kind of a broad range of peptides which are available, there are many more available, you know, like, especially in the diabetes field, we have a new peptide called GLP one which is called Victoza So, that’s another peptide that you know, which has come into the market. So, that’s a bigger broader use. Now, the question was that you know, is there any use for these peptides in adrenal dysfunction or tidal dysfunction. So, these peptides, you know, definitely work indirectly. So, like entire dysfunction, a lot of people have Hashimoto’s, which is an autoimmune disease. So, I use thymosin Alpha one a lot of times for these clients, because that helps them to reduce inflammation that balances their autoimmune process, so that we know we can improve their antibody levels and all those things. Now the other peptides which are like growth hormone, you know, like, you know, receptor agonist and all those things, those helped with sleeping. So that helps with like, you know, like, we know that sleep is essential for a lot of people for adrenal dysfunction. A lot of you know, clients after I use them, the first of all, they help them to weight lose weight, you know, like they help them to lose fat, and then and help gain muscle. But the biggest benefit they see is that you know, they sleep really very good. So I think that’s an indirect benefit for a lot of people with a dino dysfunction that these can be useful for.

Dr. Joel Rosen:
Excellent, so are those mainly used? I know peptides have to be do all peptides have to be injectable? Are they able to be taken early? How are they administered?

Dr. Anshul Gupta:
Yeah, almost all of them are injectables. Now we have a new kind of peptide is one company, which is making a BPC as an oral form, but I don’t see great results with it. So still, like, Yes, all of the peptides are injectables, the reason being I shared with you that you know, like, if you take them orally, your body, just digest them. And that’s the reason you know, like, if it breaks down in your GI tract, then they cannot function. So, we are still not in the process, you know, like, we have not yet have mastered the technology, that we have those peptides which can be taken orally, most of them are injectable, which is like a sub q injection, which is like how people give insulin injections like in a very, like, very small needle that they can use. And they can use, you know, gently around their stomach is, you know, like, or their, you know, like lower abdomen is what they use for injecting these peptides.


Dr. Joel Rosen: Okay, excellent. Yeah, there’s a lot of hope and, and, and a lot of encouragement for these peptide therapies, I have my own theory in terms of the protein demand and supply inequality. So when I do a functional medicine assessment, typically I see values that suggest protein depletion, or I tell them, there are a protein demand and supply problem where if your immune systems upregulated, and there’s lots of inflammation and stress, that’s gonna be increased demand. But on top of that, if you have microbial concerns, absorption issues, gi dis, dis dysbiosis, that’s going to decrease the demand the supply, and then ultimately part of the enzymatic construction with proteins necessity, peptide, use our peptide requirements for proteins, just the actual, the cellular matrix of the cell requiring protein immunoglobulins, requiring proteins, you’re at a loss, you’re it’s like I tell people you’re working in New York and you’re working at minimum wage, you’re not keeping up with the demand and supply of protein availability, which impacts the signaling challenges. And then to be able to give these stable peptides in an injectable form will really leapfrog ahead of some of the challenges that someone has with just taking amino acids. So that’s my theory anyway, in terms of why peptides would be so helpful. So listen, I appreciate your time. I know we could talk further. But what I want to do is I want to ask you in a follow up the last question. I always ask this of my guests, knowing what you know, now, what would you have told the younger version of yourself? For health purposes, for a better quality of life purposes for just Sage wisdom purposes? What words of advice or encouragement or wisdom would you have had for the younger anshel?

Dr. Anshul Gupta:
Well, the only advice that I found useful, and I will always in like, as he said, like, if I was like, you know, like 10 years ago, if I knew about it, is that manage your stress properly, have a game plan to manage the stress because stress is going to eat you up. Stress is going to like you know, create havoc in your life. And definitely, it builds up and you are going bound to have health issues later on. And we all ignore it. We never plan to have stress management. And the key is that start slow. Like just have a few minutes for yourself a day. You don’t have to have an hour or like three hours or four hours to kind of you know, de-stress these few minutes, but be consistent with it and use it wisely.

Dr. Joel Rosen: Oh, that’s great advice. Excellent advice. So now let’s say I want to learn a little bit more about you. I know you have some social media and some and a website. Where do I go to find out more about you Dr. Gupta?


Dr. Anshul Gupta:
The best way to learn more about me is going on our website, which is unschooled Gupta., I have an active blog on our website where you know, again, I have a more research-based person so I write a blog about various new research which is coming up, which is related to thyroid or Dino glands and all those things. So we can people can follow me along over there. Obviously, you know, you can follow me on Instagram, my handle is uncial Gupta, MD. So because I’m very active on Instagram, and I kind of post a lot of useful information over there. So people can find me over there also.


Dr. Joel Rosen: Awesome. So just to spell it out. It’s an NSHULG or is it MD in their MD in there? Okay, so a and sh ULG up TA Yeah. Awesome. And the same thing for Instagram as well. Awesome. Well listen, I appreciate your time with it. goes by very quickly. And I would love to get some more insight down the road and keep an open invitation to talk once again. And yeah, I appreciate you and your forthcoming nature of telling us your impression of what’s going on in the world and what’s going on with health. And I’m being open to the new information and applying it to your clients to help change the world and get people healthy. So thank you for what you do.

Dr. Anshul Gupta:
Well, I really appreciate you having me on the show. And I’m I really like what you have been doing, especially dealing with such a controversial topic, as you said, but that’s what we need to do. We need to talk about, you know, like tough things, you know, in this world, so that, you know, everybody has a voice, but people need it, you know, so I really appreciate what you’re doing.

Dr. Joel Rosen:
Oh, thank you so much. All right, well, good. So you have a good rest of your day and chill and we will catch up again soon.

Dr. Anshul Gupta:
Yes, absolutely. Thank you so much.


Dr. Joel Rosen: Thank you.


Contact Dr.Gupta

For the research paper by Dr. Robert Naviaux:

Get Adrenal Fatigue "Warrior" Toolkit

  • An easy to understand, guide on how to communicate with your doctor about your adrenal health
  • How to quickly and accurately identify your key reversible stressors
  • Quickly learn about the most important hormone tests that identify the problem
  • Easy, effective solutions to getting back your energy
  • My TOP 10 Adrenal Warrior Supplements with a complete video explanation