Reverse Aging: Cutting Edge Biohacks Actually Guaranteed for Healthy Aging

 

Dr. Joel Rosen: Alright, hello, everyone. And welcome back to another edition of the truth about your health podcast, where we teach exhausted and burnt-out adults the truth about their health so that they can get their health back quickly.

And today, it’s like I’m a kid in the candy store. Because SIEM is someone that I’ve been watching for a long time. I have both of his big books, and he’s got more books to even speak of. If you haven’t heard of him before, his name is seam land. He’s the author and content creator, public speaker, entrepreneur, biohacker, and health performance coach. He’s written several books, just like I told you about longevity and optimization for your health, metabolic a tough OG stronger by stress, the immunity fixes the mineral fixed. And he’s also now written another book called The NADPH, our circadian NADPH plus activation system. So seeing thank you so much for being here today. It’s a real pleasure to have you here joining us today.

 

Sim Land: Thanks for having me. And I’m glad to be here.

 

Dr. Joel Rosen: Yeah, so listen, I love your intro story, in terms of your background in anthropology. And if I were to be completely honest with you, in my first year of university, I took anthropology as an elective, because I didn’t know what to take. And it was one of those times when it was an elective for me to show up to the actual class. And I didn’t do very well, because I wasn’t focused at that time. But can you tell us how that anthropology was a springboard to becoming the credentials that we just talked about for writing books on longevity and, and health optimization? How did that happen?

 

Sim Land: Well, I, the reason I took or started studying anthropology was, I was just very curious about human nature and human society, culture, and those kinds of things, all those things. And I started Yeah, like the anthropology degree, because of that felt like, you know, the right thing to satisfy my desire to learn about those things at that time, and doing the anthropology studying I, you know, sort of think about, okay, well, like what do I want to do in the future, actually, and that kind of, for some reason, I concluded that I would like to be like a writer or Yeah, like write books and or be an author, whichever, you know, form it ends up taking, and just like the medium that I enjoyed, and yeah, doing the college years or university years, I did start to write my blog about Yeah, biohacking and health initially was just, you know, very simple, you know, just different kinds of nutrition strategies and straining and they kind of be like very simple things, and just started to grow a little bit of audience from there, not like a significant amount, still very small.

And then I did like, wrote, write a few books about a ketogenic diet, and started to sell that on Amazon, that kind of, like, yeah, that was like my first source of income online, and made me realize, hey, I can do this like full time, and do more like in more in-depth research and more thorough books, and those things. From that idea started to create YouTube videos as well. And that is where most of my audience came from, at that time, and YouTube grew quite well because I think I covered some topics that many people didn’t talk about, like, ketosis or cyclical ketosis and intermittent fasting, and mentioned things like autophagy. And you’re explaining what it is and how it works and refuting some myths about it.

And yeah, I think that it kind of helped to springboard my audience because of covering this new novel topic that many people didn’t know about. Especially the details about it, and that kind of made me I like, initial like, my, let’s say, my brand or my audience was associated with this endeavor, the fasting, and otology which I think still most of it is what I’m most known for the metabolic illogical. And, but yeah, like, regardless, that was like what I started to talk about, but over time, I implemented more topics, you know, just general health saunas and exercise and yeah, more interactive longevity stuff as well by now and wrote several books on different topics like stronger stress, which was the book about hormesis and stress adaptation.

And then I also started to co-author many books with Dr. James nickel Antonio, including the immunity fix, which talks about the immune system, and the mineral fix about minerals. The latest one was a win, which talks about actually athletic performance and exercise. And the next one that we’re working on right now is the obesity fix. So we’re gonna talk about weight loss and weight management.

 

Dr. Joel Rosen: Ya know, it’s an awesome breakdown of where you got to today, I could see how anthropology just in terms of the study of cultures, would naturally evolve as you continue to open up the next door and go through that, and then listen to what your audience is what resonates with them, and then continue to refine and, and get into where you got to. So thanks for sharing that. Just an obvious spectator question, though, seem How do you remain so productive? Because it’s, it is amazing to see how I mean, these books are thick.

And you know, and just to mention, you have all these things on the go, I guess those are your bio hacks, but specifically in terms of just sitting down and get and crushing it and getting content out? What would you say, you know, what’s, what’s the secret to the success on that?

 

Sim Land: I think it’s a lot of having very good systems and routines and habits that, put it into here, like, you know, autopilot, almost, or making it very effortless. So I have like a system for writing and have a system for making videos and social media posts and whatnot. So I just stick to that routine. And, yeah, I do think that you know, a lot of it is yeah, just a lot of like, being productive deliberately of you know, wanting to do those things and doing them.

And not like, you know, wasting time or something like that, of course, there are days where I don’t follow the systems and, but those are like, the exceptions because a lot of the most of the time I do enjoy it so much that I want to do it, like I’m so excited to write the next book that I won’t write it every day, and doing it, you know, quite many hours. So, yeah, it’s, you know, just being very passionate about what you do and excited about what you do that the work doesn’t feel like work.

And it’s very, like enjoyable, it’s, you know, very, very useful to also, you know, have that work that you do a part of your life or it kind of meshed with your life in some way. So, yeah, obviously, you know, I think it’s a very, very good, quote, unquote, job, to take care of your health, and learn about nutrition and exercise and those things. So, yeah, I’m kind of, you know, happy that I’ve managed to create this lifestyle for myself, that prioritizes, you know, my health and being able to also share that information with others that I’ve learned.

 

Dr. Joel Rosen: Yeah, I think that’s one of the reasons that it’s so resonating for me is the integrity that’s there when you practice what you preach. And it is something that I can sense that you’re passionate about, and it’s not working for you. I guess the biggest success comes with that focus, just like if you had a Microsoft, magnifying glass, I know when I was a kid, I used to like to shine it and then make a piece of paper, go on fire because it’s so concentrated. I think the real lesson is in how you organize, and the systems you’ve come up with, to be able to consistently churn out content, just as feedback for me, my biggest concern is, when I start to do that, I get so overwhelmed that I wish I have so many things I want to put in there.

And for you, it’s the same thing, I’m sure but you turn it out anyways and then say, oh, I’ll just, I’ll write whatever I want to write in the next book that I can include on there. So kudos to you. I’m still in like the seven books that are in my head that I feel I have to put in one book. But so So let’s kind of shift over into longevity and circadian rhythm. So as far as my demographic is the people that would listen to this identify themselves as having an adrenal fatigue problem, and I tell them, Listen, it goes more than adrenal fatigue, the adrenals don’t fatigue per se.

90% of the challenges occur outside of the adrenal system and all the feedback loops and communications. But besides that, I don’t even feel HPA axis is a good term, either be dysfunction because it’s just so much more involved than that. But the whole point is we do understand and most practitioners, whether they’re allopathic or traditional or alternative, understand that there’s a dying neural pattern or there’s a circadian rhythm with cortisol and it rises in the morning and then falls at night. But maybe you could start to explain how much more circadian rhythm is beyond just the HPA axis and why it matters so much.

 

Sim Land: Yeah, well, I think circadian rhythms are just the overarching rhythms of your body that govern everything inside that happening daily. There’s also like, you know, old ultradian rhythms that are longer than the 24-hour cycle, but the main, like, what happens constantly? All the time is the circadian rhythm. 24-hour cycle. And, yeah, they govern as you mentioned, the nervous system and the HPA Axis function, but also things like digestion, intimacies, activity, energy production, exercise performance, your body temperature, and blood pressure.

And many of the longevity pathways are also linked to the circadian rhythm. And I think that you know, the circadian rhythms are one of the most overlooked and underappreciated aspects of longevity and anti-aging, which we can probably talk about a bit more in detail. But yeah, essentially, disruptions in those rhythms will cause or the reason why these disruptions are harmful is that they’re going to put like more additional stress on the body and inflammation rises, you have listened to this activity, and everything to get things started to like, go wrong.

And the like. One other example of that would be shiftwork, which the World Health Organization does categorize as a carcinogen. So just being mismatched with the circadian rhythms, causes disease and being aligned with the natural circadian rhythm, which humans are like diurnal creatures that were awake during the daytime and asleep at night, that is where your body, you know, is synchronized and aligned with how it’s supposed to work, it receives the signals from the light environment, and that light will tell the body, okay, you need to produce these hormones, and you need to govern these other processes, so that you could stay healthy.

This Yeah, like, just to kind of the rhythms themselves are yet like signals or processes coming from the signals that you receive, like different signals, like the light or food or exercise, they will just tell the body, okay, this is what you need to do. And this was, what the human body’s like, evolutionarily adapted to do, as well. And if you’re not aligned with them, then it’s gonna cause some sort of disease. I mentioned them.

 

Dr. Joel Rosen: Yeah, 100%. And I think that it echoes how important stress and just our day-to-day exposure, and our communication with the Earth have to do with adrenals and HPA axis and cellular function as a whole. And I know you’ve interviewed David St. Clair, and he talks about how aging is a breakdown of communication.

And I believe that the frequencies and the signals that are happening on a level that we don’t realize, finely tuned and synchronized our body and it’s amazing, you’re right, it’s under-appreciated. And the great thing about it is it’s free. You don’t have to patent it. You can I tell my clients if you just go camping, and not glamping you know, you don’t bring your cell phone, you just go camping, do that for a week.

And that’s probably one of the best things you can do for your body to get re-acclimated to the earth. As far as how would Where does NAD plus comes in and you said we can get into a little bit of the aging and so maybe tell our listeners what, is NAD plus and what does it have to do with circadian rhythm and aging?

 

Sim Land: Yeah, well, NAD plus translates into nicotinamide adenine dinucleotide. And it’s an enzyme inside the body that is also involved with everything you do. It’s like a currency that is being used to produce energy and regulate the immune system and DNA repair. The circadian rhythms are using that and yeah, like muscle function insensitivity again are using that and it’s like ATP almost, you need like NAD to shuffle around electrons and things like that.

And with about aging, there is a drop of NAD that occurs with aging as you lose almost all like over 50% of your NAD you lose after the age of 40 Generally, low levels of NAD are associated with all the hallmarks of aging like cellular senescence, loss of proteostasis or otology and dysregulated nutrient sensing and The Genomic instability and DNA damage and telomere shortening, they’re all caused by low levels of NAD. And there are there aren’t like, you know, a lot of studies where they use NAD like, you know, extended lifespan compared to some other molecules and compounds. But they are still, I’d say, crucial for maintaining a good health span, which relates to just you know, being functional and being functionally fit for as long as possible.

And when it comes to the, you know there are many ways to boost NAD levels, like exercise and interval fasting calorie restriction. Those are natural ways to do it. But one key part of doing that as well as the circadian rhythm alignment. Because you know, there are like a lot of these energy-boosting supplements that you can take like an Amen, and you get to the enema driver side. But the problem with only taking like this supplement is that unless your body’s natural, NAD factory or mechanism, the production line isn’t working properly, then you’re gonna just take the supplement, you may get like a short term boost in it, but your body is gonna excrete the rest, and it’s not going to start making it.

It’s not like, like, yeah, you’re not making the body produce entity itself if you’re taking a supplement. Whereas if you have the, essentially the production working well, then you can also just help to recycle the entity all the time. So you know, you can get any different food supplements or have the NAD salvage pathway or the recycling of NAD working very well, and not exactly sure the percentage of the amount. But they do approximately that the vast majority of the NAD that you produce daily comes from recycling and research. So yeah, maybe like after 90% of it. That’s what I’ve heard 90% of the energy you have every day is recycled daily.

And only like 10% will come from the precursors from foods or supplements. So you need to have the recycling pathway working properly to have high levels of NAD. And the way you recycle the NAD there is this one key enzyme inside the salvage pathway where you produce NAD and NADP T is what it’s called. And this name enzyme is circadian rhythm dependent. So it’s dependent upon a certain one, which is the circadian clock, Gene protein. And yeah, basically what it means is that circadian signaling is what will tell the body that it needs to turn on the salvage pathway.

And I would suggest that you know, most of the entity gets recycled when you’re sleeping in because that’s what the body tends to do to kind of clamp all these repair and rejuvenation processes into the night in together with like melatonin and other hormones. And during the daytime, it’s just your signals the body that kind of installs this information in there of being aligned with the circadian rhythms and then enabling the body to also produce melatonin at night to govern all these repairs. But yeah, I think I’ll stop here for a moment. So the main idea is that the circadian rhythms will enable the cycling of recycling of NAD and keep your energy levels higher.

 

Dr. Joel Rosen: Yeah, no, it’s a great answer. And I want to kind of link that to some of the analogies you use in terms of other recycling and the assembly line. And what I’ll add to that is the widget, which would be the end product, but also how fast that assembly line is moving. So when I talk to our clients, I always do that analogy of supply and demand. Just think of it as you have more demand than you do supply.

And or I use another analogy in terms of having too many on roads to your highway and not enough off-ramps to your highway. And when there’s too much traffic on there, you need to you’re going to deplete your NAD. And you need to make sure you open up your off-ramp so that you can take the cars off the highway, so a lot of different analogies. But what increases the speed of that assembly line or the on-ramp to that highway is environmental stressors that I don’t think we ever really planned for in terms of EMFs pesticides, sprays, growth hormones, in our foods, plastics in the environment, enriched iron in our foods, fortification of B vitamins in our foods. I mean, the list goes on and on.

And actually, it’s just a good segue. There was a guy that I talked to that invented the first-ever NAD plus testing at the last forum meeting and I asked him, I said, Well, how? How is that going to be a good predictor of the number of cars or how fast that assembly line is running? If it’s constant, and it’s always there. So I guess the question would be to use seem, do you see the utility and being able to test NAD plus or NAD plus to NADH ratios? Is it’s going to have high value? Or do you think it’s just a snapshot in time, that’s not predictive of the future and past? I guess the quality of your demand and supply in your body? What’s your feedback on that?

 

Sim Land: Yeah, I have had like some similar experiences that it’s very, very like sensitive to a lot of factors, like most of what he was going to reduce your energy levels are going to be like inflammation and oxidative stress. And yeah, EMF or whatever it is food, sleep deprivation, whatever raises, like inflammation, and causes DNA damage, that’s mostly going to burn through the NAD as well.

And I do think that the results could like change very rapidly. So for example, I did like the test. Maybe like, yeah, like I did the test, my levels were high. And I did a test maybe. And at that time, I was like, you know, very optimally functioning. And I did the test again, maybe like a few months later, but this time, I wasn’t like, you know, very optimized, or I was like, a bit undersized. And those kinds of things. Because I think a lot of those. So my results were a bit lower. Because of that.

And I do think that it’s kind of, yeah, it can be like very sensitive to the changes in your like lifestyle and what you’re doing daily. So I don’t want to tell you that. It’s something to like, you know, put a lot of long-term emphasis on it. Yeah, it’s maybe like a snapshot in a particular moment to know like, Okay, what am I gonna do right now, but it’s not going to tell you anything about long-term health changes, or it’s not going to be like a predictor of mortality, we wouldn’t just so more like the biomarkers themselves are more valuable, and definitely cheaper and more easily accessible. So I’d much rather focus on them.

The same as the DNA methylation test that is used to assess your biological age. It’s also very sensitive and can change very rapidly. So it’s, yeah, more like a snapshot. So I don’t see as it does like have like a lot of like long term value. It can be like, again, used in the short term to know what’s your status, and health status in a particular moment, but not very practical in the overall long term.

 

Dr. Joel Rosen: Yeah, I agree. I’m glad that you echo that. Because I do feel that there’s a lot of other great surrogate markers for assessing metabolic syndrome and which was interesting, you know, in your latest circadian NAD plus Activation System book.

And it’s amazing how many references you have, like, there’s no BS saying it’s all validated through substantial reference material. One of the interesting things that I just wrote down quickly was, you quoted a study that said in between 1988 to 2012, there was 34% of the population that had metabolic syndrome. But in the United States, now, 88% of people have metabolic syndrome. And I think that there are great biomarkers like triglycerides over HDL fasting insulin, such as TLT.

Other great markers that you can get every day that doctors aren’t looking at from the broad, broad ranges. But let me ask you, just your opinion on that between 1988 and 2012 34%. And I know it’s not the same cohorts that we’re testing, or maybe the same people, but then, you know, now 88%, what do you think so? Even if it were apples to apples, what do you think’s been responsible for that huge, dramatic increase in how many people are sick metabolically these days?

 

Sim Land:  Well, maybe it’s something to do with like a generational shift or something like that the older generation who was kind of healthy has died. And now there’s like the quote, unquote, like a new I don’t know, like Gen. Or Millennials or I don’t know who I don’t know exactly what how do they call these different generations, but yeah, like maybe this older generation who was you know, back from the old day where they ate Whole Foods and exercise a little bit or you know, be they spent like time basically like a pre-internet generation and pre creat this TV generation, those who have all died, and that like just increased the mean or the average rate of this Metabolic syndrome in the population.

Because they, you know, everyone after that was kind of more the TV generation TV dinner generation and that kind of thing. So just I think maybe like, that could be like a sudden increase in that. But obviously, just the more wide accessibility of junk food in the environment. I think that’s the biggest cause of all these diseases, and not even like the lack of exercise, but I think the biggest one is just the food, the sheer excess of calories everywhere and in every food and kind of the ease of access as well. Like just the vending machines, Uber, Uber Eats all the Starbucks cups of coffee everywhere. So yeah, just people consume too many calories all the time everywhere.

 

Dr. Joel Rosen: Yeah, that’s a good anthropological answer for sure. I love it. You know what, I’m older than you. And we didn’t have cell phones. And we were just starting to get Atari and the television but you know, Amazon Prime delivered in 24 hours and just the 5g Let alone if there are six g pesticides and sprays, it’s just created an avalanche of huge challenges.

So I like your answer. But I also feel that environmentally, I mean, I think it’s going to Estonia, you have more regulations about what you can put in foods and how you can spray the crops. And it always comes down to the almighty dollar, unfortunately, and I think we’re seeing huge shifts and, and health as a result of that. But back to what we want to talk about. You did mention in terms of the NAD plus that what I do, again, with Gene interpretations is now looking at sirtuins, and the sirtuins can tell the body Hey, the assembly lines working fast. There’s a lot of inflammation, a lot of environmental triggers all the TV dinner generation, not as much exercise not as much communication with the Earth, too many foods, and overconsumption of processed foods.

And then they say NAD plus, in de novo factories, start making more NAD plus, tell us how we can do things naturally because that’s what you talk about between resetting the circadian rhythm and everything else in between. What’s the what can we do naturally seem to get those factories working at full throttle?

 

Sim Land: You Yeah. Well, you mentioned all these bad stressors, EMF and food, and pesticides and those things. Yeah, things that cause inflammation and oxidative stress, and DNA damage, generally will deplete NAD. And because energy is being used to kind of treat that situation, whereas all these different kinds of positive stressors hormetic stressors, as they call that exercise in order fasting calorie restriction.

So when I called sunlight exposure to a certain extent, and there are different food molecules, because you know, hormetic food molecules, Resveratrol finds it in apigenin. Yeah, like its polar phenols, coffee, and green tea, those also help with their recycling and the salvage pathway. So they do it by turning on the fuel center called an NPK, which is like an energetic stressor, or detects energetic stress in response to we like usually physiological stressors.

And that in turn also helps to turn on the amp enzyme to recycle the NAD levels. So yeah, all your healthy lifestyle habits. Exercise, I think is kind of the most underrated way of, as we said, the circadian rhythm is the most underrated. But exercise is yeah, like the most powerful, like anti-aging activity and longevity thing is more powerful than any, like any drug or any supplement that currently we have.

And it has a huge impact on NAD levels as well. They see that older person who exercises have much higher levels of name in their muscles as well. And even they may have more EP T levels than, let’s say younger adults who don’t exercise. So yeah, just, you know, exercising itself is going to be one of the biggest ways to, let’s say, put the factory into overdrive or to start producing a lot more NAD both as you know, resistance training and cardio would do it but I would suspect that cardio and this kind of zone to cardio, as it’s called is very semi-low intensity, long cardio, that I think it’s going to be the best way to kind of produce more mitochondria for much, much Kandra biogenesis but as well like help to boost NAD levels. Then from the food side, the food is also like a cue for the circadian rhythms.

And you don’t want to like you know, be eating at, like all hours or eating in the middle of the night, that kind of things that those will also offset, the circadian rhythm is disrupted. So humans are not supposed to eat when it’s daytime. And studies about Thomas eating do show that confining your eating window in a smaller timeframe has some health benefits. It’s not like superior to calorie restriction in terms of weight loss, but it can improve things like incidences of activity and upregulate different longevity markers like sirtuins and ontology more than just regularly eating over 12 hours.

For example, as many people do, the average American, you know, eats over 15 or 16 hours. So that’s like not what I would recommend, I wouldn’t, I do think that it’s better to like wait a few hours after waking up and not eat immediately before bed. So have like a few hours from bedtime as well to finish your last meal. And then eat maybe like, you know, definitely like not more than like three meals isn’t necessary. So two to three meals within like a more like a smaller timeframe. And the circadian rhythm side, just that from for that you just need to kind of establish like a consistent bed and wake time. So you go to bed and wake up around the same time.

You do want to get exposed to like natural sunlight, most, most importantly, in the morning after waking up to start the circadian clocks. So just this UV light from the sun, that will be very, it’s going to be much more powerful in terms of the brightness and intensity, even if it’s cloudy than being indoors. So being indoors doesn’t you know, enable you to start dislocating and read more if that doesn’t do it. That is the healthy way. Whereas if you go outside after waking up a little bit, maybe five or 10 minutes, that will already tell the brain that is your daytime.

And it’s also actually just basically like you know, it’s like a domino stone. It’s the first domino stone the most important one that will just push the circadian clock working in the right direction. And in the evening, you want to avoid these like bright lights, blue light, green light, because they’re going to suppress melatonin and disrupt your sleep quality a little bit and kind of disrupt the clocks as well. So bright light movement, hydration in the morning, in the evening, just you know, avoid snacking, avoid large meals and block the blue light as well. I think that’s kind of one of the main messages of the circadian energy activation system as well and the main like, practical applications of that.

 

Dr. Joel Rosen: Yeah, no. It’s amazing. It’s that this dichotomy seems of how complex it can be, but at the same time how simple it could be, right? I mean, this isn’t rocket science to tell someone, hey, you need to go to sleep properly. And you don’t need to be eating 24 hours a day. And you need to get outside and be part of the earth. I mean, those are common sense stuff. But then when you start talking about foxes, and sirtuins and 80 Plus, sometimes you could lose someone if they’re not into that science. But for the listener, I mean stronger by stress metabolic a tough OG will have links for that as well as their circadian NAD plus activation. I know you give a lot of weight things for free, intermittent fasting guide, I guess the autophagy activation, cheat sheet, sleeping for better, sleeping better, a free guide.

So I’ll have the links for those because I think the other thing that I have to commend you on is not just how productive and how amazing your information is, and how prolific you are, but how you give a lot of it away for free so that people can learn this information. So thank you for doing that. As far as a toffee G goes, and you talked about intermittent fasting and we have time-restricted eating windows or we have different strategies like five and two, and then, of course, full fast and a toffee G can you speak a little bit about that because one of the products that I’m developing or names that I’m developing is something called catabolic to anabolic.

And the analogy I use is you can’t drive with your foot on the gas and at the break at the same time. And there’s a fine line to that meaning if you’re not eating a lot, but then maybe you’re getting a weight loss you’re lifting a lot of weights, or if you’re doing a lot of mTOR stuff, but you’re wishing to turn on autophagy? I mean, can you talk us a take us through maybe the different types of food restrictions and ultimately how to not drive with your foot on the gas and the brake at the same time?

 

Sim Land: Yeah, that was kind of the main topic of the book metabolic physiology. And there are, you know, reasons to think that you shouldn’t like different like growth periods, people can go through their life as a like a child or a baby, then you’re growing a lot like your, you know, in terms of the percentage you grow, like, you know, very large, like you doubled your size in one year, or something like that. So you’re the ratios increase exponentially when you’re young.

And in your like, after puberty, it kind of starts to slow down a little bit. So you’re not, you’re aging the most or the fastest when you’re like young, in terms of the changes, you go through the fastest, and it kind of plateaus in your 20s and starts to slowly, basically, accelerate or the process of aging slows down when you’re in your 20s and 30s. And then you start to see more, these visible and significant changes, after you’re in depends on when it happens. Like if you have you know, a good, healthy, healthy lifestyle, then you can prolong it. But if you have like a bad lifestyle, then it’s gonna start to happen again, in your 40s, or 50s.

Already, let’s say compared to the 60s or 80s if you’re healthy. So yeah, but yeah, different growth periods, if you’re young, you do want to grow, you want to build, you know, bone density, and get a lot of nutrition and nutrients into your system, so that you could grow and develop properly, physical features and brain and that kind of things. If you’re old, then you also like and want to support the growth, not because you can grow, but for maintaining the things that you have.

So if you’re like, let’s say 60 or 70, then what tends to happen is that your, like muscle mass decreases, because of many reasons, some people say that it’s, you know, you lose sensitivity to stimulate protein synthesis, you just become sedentary, that kind of things, whatever it is, like, there is like a significant trend in losing muscle mass if you get older, and you’re not able to build it back up either that easily either for different reasons. So yeah, in that scenario, you do want to support that growth as well by, you know, you’re eating more protein and, and getting amino acids and those kinds of things to maintain that.

And likewise, when you’re young, you want to do that as well to kind of grow and produce our growth hormone and anabolic hormones to grow. It’s like, Yeah, a bit controversial in terms of Do you want to do that all the time in your life? You know, if you’re in your 20s until your 40s or 50s, do you want to do that all the time? There is like some animal studies, animal research that suggests that yeah, like being in this growth state all the time, by being anabolic, and turning on this pathway called mTOR.

And increasing IGF one levels and growth hormone. Is that the most beneficial thing to do in your like, middle years or Yeah, because there is like restricting protein, restricting the mTOR is beneficial for longevity in some sense. But yeah, like not all the time you don’t want to do that. If you’re like still growing, if you’re like a teenager, and even like in your 20s, maybe you don’t want to do that that significantly. You want to still, you know, be strong and build muscle as well in your younger years. Because it’s easier to do that. In your older years, you may not want to do that, or this restrictive approach either that much-restricting protein because that would entail that you will become frailer.

And that can be you know, harmful for sarcopenia and metabolic health in general. But yeah, I do personally think that there is some merit to going through these different cycles of growing, of being in a more anabolic state, and also going through stages of being more catabolic. Because during that catabolic state, you do see an increase in all these different longevity markers that we mentioned already, like FOXO proteins, sirtuins, autophagy, and NAD, and, yeah, those vary more associated with increased lifespan and longevity.

And the same applies to just calorie restriction, too. restricting calories is one of the most known ways to extend lifespan and others. Some people think that it’s not the best thing for humans, which can be true because you know, if you can’t restrict then you also become frailer or you decrease the risk of nutrient deficiencies, so you need to do it well and you need to and maybe like cyclically, not all the time. But fortunately, there are some ways to mimic some of these effects that you see in color restriction within the fasting we do see almost identical,

like identical, changing biomarkers as you would in calorie restriction. And the same applies to exercise like exercise mimics calorie restriction. So, yeah, you can apply, you don’t want to become over-nourished. You don’t want to become obese, you don’t want to become overweight and develop metabolic syndrome. You don’t want to be in this Yeah, over nourish the overfed state overabundance state all the time, you want to have like some periods of restriction, whether that takes the form of calorie restriction, restricting some sort of like the time window that you eat, or maybe doing like a longer fast, whatever it is. But I think the reason why fasting can help with the longevity thing is that the chair kind of prevents you from getting obese or prevents you from getting overweight.

And the same with the way it works with calorie restriction as well. So just some people may prefer to do like longer fasts and not restrict calories at other times, whereas others prefer to do just a regular calorie restriction, and then eat appropriate that maintenance or whatever. So yeah, I think that’s the kind of mean idea to cycle through periods of growth and some sort of cannibalism, but you don’t want to be in a very low-calorie state all the time. And when it comes to protein restriction, then yeah, I do think that yeah, you may be not eating a high protein diet all the time is the best idea. So it cycles that as well. But being on a chronically low protein diet can also be harmful. Because we are just increasing frailty, risk, and sarcopenia. And not being able to build muscle so we are approaching can be very beneficial. Just you may not want to be eating a super high protein diet all the time.

 

Dr. Joel Rosen: It’s a great answer. One of my mentors has said everything we learned in life can be extrapolated from Goldilocks and the Three Bears not too much, not too little, but just right. And I think depending on where you are on your age and your life cycle, you’re putting more emphasis on building.

And then as we get older, you still want to maintain strength and mitogenesis. But you also want to make sure you’re recycling and getting into a toffee G. I do think and you’ll agree with me seeing that the bodybuilders are the original OGS of biohacking, right, they understood this concept intuitively, even though they may not have known about the term autophagy or mTOR. I use the analogy almost like thinking about a farmer’s field. And they plant a lot of crops and the soil is very new.

And they’re getting the most yield out of that soil in the early years. But at the end of the season, they got to go in there and turn the soil and recycle it so that they can repopulate the field again and rotate the crops and keep the minerals high. But as that field has been living for 8090 years, its emphasis is more on recycling those soils and just getting good high-quality nutrients. But maybe they’re not looking to get the most amount of yield like they were 50 or 60 years ago, but they’re still productive. I think that’s a really good analogy in terms of what you just mentioned.

And of course, modulating protein is a huge way to change that. Especially you talk about which is at there are so many things I can ask you, I love how you get into my dining and glycine. I definitely would love to talk to you about that. But before I do, the same, what are your biomarkers? I know you have the aura ring, as far as objective markers that you look at, or what some AHA is that you’ve had with your readiness or your sleep scores or your recovery or objective markers that you look at, even though I still think subjective is most important.

But what are some of these aha hours that you’ve had maybe that you could share with us that you’ve seen in these objective markers, whether it’s day-to-day testing, or it’s month to month testing with markers, but what are some of the things that you’re seeing with your own body that gave you some aha was with?

 

Sim Land: Well, I think from my bio work or my blood work, generally I can see that when I’m doing like, you know, the fasting and eating like, you know, once or twice a day, then my biomarkers are generally very good. So I don’t see any of these adverse side effects that people tend to talk about, like, I don’t see. Loss and Muscle I don’t see in low thyroid, I will see high-stress high cortisol, I don’t see high blood sugar or that kind of thing.

And funny enough, like even like, you know, yes, like, it is true that fasting lowers things like IGF one, which is can be good for some for anti-aging purposes because it is associated with like cancer and aging. But in very high amounts, but like low low levels of IGF, one can also be bad because it like, increases the risk of muscle loss and frailty, those things.

So obviously, I don’t have any of those things, but my job IGF one levels are still very low. And the reason why I think that he is low is because of the intermittent fasting. So because I still eat a high protein intake. So if I were to eat the same amount of protein across like three, three meals, or five meals, then my IGF one levels will probably be higher. But because I’m eating in a smaller timeframe, then it kind of compensates for that and keeps the IGF one level, or the overall IGF one level low. As a result of that.

My sleep isn’t suffering from the university, either. It’s good, I do get away, I do sleep, like, a bit less than, like an average person. Maybe I’m just, you know, kind of used to it or, but yeah, it’s not like, I don’t sleep. Eight or nine hours, I usually sleep like, you know, six to seven hours, something like that. And it hasn’t had any, negative effect on my biomarkers, or my blood results. So those things are still good. Like, I don’t have a high blood sugar level, even if I sleep less, which is usually what’s going to happen with not sleeping enough. So I still get like adequate recovery. My deep sleep is great. My HRV is very good. Like it’s super high. It’s and I think that reason why it’s high is because of again, like exercise. Someone asked maybe about exercise and investing I think are the biggest reason that my HRV was high.

 

Dr. Joel Rosen: Yeah. No, I mean, I wouldn’t expect it to be otherwise. I think that when you’re dialed in as much as you are and go back to what we initially talked about is like you don’t have to force yourself to get up every day and dial into what you do. Because you love it, you’re congruent with what you’re teaching, you follow your practice and what you preach. And, and you’re doing these, you mentioned, as far as we’re on not only on a dye neural rhythm, but we’re on an on a sort of seasonal rhythm as well.

And I think that’s important where when we go into the summer months, and there’s more fruitful, we can do more calories we can grow and but then when we get into a sort of a fall in the winter, were engineered to be more of a slower type of not as much calories do you do stuff like that as well seem in terms of the year and what time of the year we are and sort of whether it’s the foods that are available at that time versus eating foods that are imported and eating stuff that isn’t but are you aware of that as part of your, your bio hacks and longevity strategies personally?

 

Sim Land: Well, I do think I do a little bit of it. Just like intuitively or, or just because I like to have like things growing in my garden at that time. So in summer, I would eat more things coming from my garden. And that winter time, I would still eat, you know, occasionally foods that aren’t for that season. Like maybe like, I will still eat some like, I don’t know, oranges or tomatoes in winter. But maybe like a little bit less, probably. So yeah, I do in the summertime. I tend to be more like fruits and or a bit higher carb and the winter maybe like a lower-carb more a little bit. I do you just usually regulate that based on my activity levels. And if I’m more physically active, then I’ll eat more carbs and less, then I’ll eat fewer carbs. So just maybe in the summertime, I’m just generally more active.

 

Dr. Joel Rosen: Right? It’s more of a natural, just what’s available and intuitively how you’ve been? I mean, because you’re so I guess dialed in with the resonance of communication of what’s going on with the Earth, which is great. I did mention to you before we started today that I wanted to do a genomic interpretation so that we can see what some of the challenges are maybe from a genetic leave more susceptible? Where would the weak links in the chain break? If enough epigenetic triggers caused that to happen?

I guess, you know, with David Sinclair, you mentioned about maybe 20% of our expression is genomic and 80% is epigenomic. How big are you are small? Are you into understanding some of the genomics and if they’re as important as you think they are, as people say they are just I know, with DNA methylation is a big indicator of aging as well. But as far as just how much credence do you put into that?

 

Sim Land: Will the Air Force for some things it can be, yeah, very important, like MTHFR is going to be huge. And things like April eg in is going to be also very important. You know, whether you’re a fast metabolizer of caffeine or slow, I think that’s very important. So yeah, I do think there are a lot of very important things that you can learn from genetics that can even be like new life-changing. So some people are poor manipulators, which can be fixed very, quite easily.

 

Dr. Joel Rosen: So yeah.  Right. So and again, I agree with you in terms of it’s important to know from a pharmacokinetic, or, you know, as understanding how things metabolize or how they impact your body. And, for me, it’s not so much this gene does that and just gene does this. It’s the whole nutritional epi genomic genetic susceptibility, the blueprint, the roadmap, the landmines, the GPS settings, to know where you’re going and what you need to do to change gear. So in respect of your time, Sam, one of the things that I asked as a parting question is, you know, the name of the podcast is called the truth about your health.

So what truth about how do you know now that you didn’t know when maybe you were just starting the anthropology and didn’t know all the doors that you were gonna go through and talking about intermittent fasting and ketogenic diets and autophagy? And mTOR? What do you wish you knew now that you didn’t know that is what truth is? Is that revealed now that you may have thought was not what that was the opposite? Or was told that it was true, but it wasn’t? Then what would you think that would be for just your life and what you’ve learned so far?

 

Sim Land: Well, I was already doing like, you know, fasting and keto, and things like that, when I started college, even before that. So I think I think, you know, what, what has maybe has changed a little bit, is that I think, right now, I think that, like, this carbohydrate intake, and even like, you know, grains, and those kinds of things aren’t as bad as people may think, I think they can still be part of, you know, they can still be a part of like, a very healthy lifestyle.

And just people usually have like negative experiences with them, because of past experiences, or someone told them that they’re bad or something like that, from my own experience, I don’t have any adverse effects from that. And it’s, it comes down to, like, energy balance. And yeah, like your biomarkers, if you’re still very insulin sensitive, and very metabolically healthy, then you can get to what you should get away with, you know, carbohydrates, and, you know, sugar is like, normal quantities, obviously, nothing like excess, but you don’t have to have to think that any piece of you know, bread, or any piece of, you know, some sort of carbohydrate or sugar is gonna kill you, or it’s gonna give you insulin resistance or diabetes.

 

Dr. Joel Rosen: Yeah, I mean, I guess the aha for me is that you’ve been dialed in your whole life pretty much. And I think that for the listener, I agree. 100%, like Michael Phelps, when he’s exercising as much as he has, he needs to eat more calories to match that energy expenditure. However, I would just put the asterisk all things being equal, I would agree with you. But given that we’re in the US, and there are still massive amounts of GMOs and sprays and so forth, it makes it difficult for, unfortunately, the socioeconomic impact of things that get taxed or things that get supported and how much more expensive it is for the average person to get stuff that isn’t adulterated, but 100% All things being equal.

I agree. 100%. Any other last comments or things that we didn’t talk about that you want to mention? Or I’m in the listener? I’m sure have already heard of you, but I will leave a bunch of free information for them to get access to what you publish and what you do. You did mention, I guess the last question would be you did mention you have another book coming out. So what’s new on the horizon for SIEM? And maybe tell us about your, your, your organization or what you’re planning with your, with your sustainable protein sources?

 

Sim Land: Yeah, well, the next book, The obesity fix is going to be maybe like in summer, we’re gonna expect to release that. It’s gonna be just, you know, what is promoting obesity the most? And what are the kinds of most? Or what is the reason why people are eating so much? And where do those that food and calories come from? How do you like to help them mitigate that and reverse, obesity?

And yeah, but also working on this, like, hemp-based Grenell that is, has high protein and is basically like a plant-based protein source. That, yeah, it’s just like an alternative to things like Beyond Meat and these other burgers that tend to be very bad in terms of ingredients and to your health. So we’re one I just want to create like a plant-based meat alternative that is good and has clean ingredients and doesn’t have anything else artificial. Just you know, it has only hemp flour and pea protein. So it’s 100% like, you know, natural. No, that’s awesome.

 

Dr. Joel Rosen: I’m excited to see that when it comes out. But Sam, I want to thank you for your time, I will post the links to all the resources that we talked about. And I look forward to continuing to follow you from the fly on the wall, so to speak, and seeing all the things that you’re doing and just want to thank you for giving me your time today and everything that you do. So thank you so much.

 

Sim Land: It was my pleasure.

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