NAD+ Explained | Reasons why it’s absolutely critical to healthy aging


Dr. Joel Rosen: Alright, hello, everyone. And welcome back to another edition of your adrenal fix podcast where we teach exhausted and burnt-out adults, the truth about their health so that they can get their health back quickly. And today, I’m joined by an expert in the field. And it’s a real pleasure. I told him, I’m like a kid in the candy store today.

I’m here with Gene Shan Shan, who is a Ph.D. and he is the CEO and founder of GE infinity precision medicine. They are a longevity biomarker company that is aiming to maximize your health span by testing biomarkers and yielding precision nutraceuticals that focus on NAD and senescence testing around the global market. So Dr. Gene, thank you so much for being here today.


Dr. Jin-Xiong She:
It’s my pleasure. Thank you very much.


Dr. Joel Rosen: Yeah, so I met you earlier, you probably don’t remember, but you were at the A 4 am meeting. And I got my NAD test result, which was very, very low. And it was a shocker sort of smelling salt to see because I’m helping other people with their health. But ultimately, I’m kind of curious, I always asked my guests a little bit about their background story. And I know you’re in teaching and research. And you’ve been well known for your teddy study that screens hundreds of 1000s of newborns for HLA, Dr. Q, Dr., And DQ, I’m curious how tell me maybe a little bit of how that transitioned into longevity and NAD.


Dr. Jin-Xiong She: Sure. So I have been an academic researcher on warm water for decades. And, my research, has been having a wide range of topics most of my research focused on childhood, diabetes, or type one diabetes, and we were trying to identify the genetic and environmental factors that cause type one diabetes, and doing during my studies, I have developed expertise in biomarkers, and was also appendix, and that the knowledge and the experience we gained through over the years can be applied to any diseases or conditions or biomedical question you want to be answered. And now about five years ago, I went to a meeting and met a functional medicine doctor in Florida.

And we started talking about longevity, biomarker testing, and why biomarker testing would be important to the whole failed field of functional medicine and longevity, in particular. So I have been interested in longevity now because you know, I’m getting to an age where longevity become important, I needed to do something for myself. Because I don’t want to be one of the people who are going to be not mobile or not functional enough, in their 50s and 60s, or 70s.

And if you look at the statistics, most of the aging-related diseases started occurring in the 50s, and the 60s, and our knife then is majorly reduced by the development of new Kornek aging-related diseases. So if we can come up with ways to prevent this condition, we should be able to extend the people’s lifespan, or at least the sales of spam by a decade, two decades, and even three decades. So that’s why you know, my interest has very kind of suddenly and rapidly turned the former childhood disease to an Asian relating that problem. And I’m very happy that I made the switch because I think I’m able to help myself, have my family, my friend, and work to help who the community needs to be a very exciting time. Sure.


Dr. Joel Rosen: It’s exciting to hear your background. Thank you for sharing. I would also add that when you isolate a great predictor and assessment of the biological age and the chronological age via NAD, specifically intracellular NAD, then the type one diet diabetic children would stand to benefit with everything that you’re going to be doing to support the environment and the boosting of intracellular NAD would still not only help with longevity and health span and aging well but for sick people to heal quicker as well is that a correct statement.


Dr. Jin-Xiong She: Was needed. So we haven’t we looked at adding a few 1000s of even the biomarkers, three, four years ago, to come up with the data, maybe at most 2002 biomarkers that are most relevant to health performance, and longevity. And what came up at the very top is an ad. And, you know, that makes sense, because NAD is a coenzyme, that is important for the function of over 400, adding them without the NAD on is in times within a function at a wall.

So even if policies don’t function, then we don’t have health we even don’t have nice. So it is not only important for aging-related diseases, it was important for pretty much war settlement functions and health, and was important for almost all war major diseases. And We have indeed found only the deficiency in people with many different diseases. Right, it’s still


Dr. Joel Rosen: We could say it’s a very sensitive marker that will predict whether or not you’re, you’re heading in a good trajectory or not. Or maybe you’re already in a challenge, and you’re not aware of it. And it’s really good to be aware of what you have that you don’t realize that you have because it makes you take more accountability for your health. After all, you could see it in black and white. So I guess I guess the question is, now that you can measure the intracellular NAD, maybe tell our listeners why that was a problem in the past, or what the difference between circulating NAD and intracellular NAD is and how you were able to come up with testing it.


Dr. Jin-Xiong She: Sure. I’m so needy, like many other molecules, ah, usually located inside of the cells. But a part faction of them can be a secret in Warren renice, from inside of the sales into the outside space, and then they got into the bladder certain nation. So that’s why I call the NAD in the liquid part of the blood that we call plasma, circulating NAD because the blood circulates with the body, and NAD was to circulate all over the body. And that’s going to be very important and probably in the later part of our discussion, because circulating in the hive has very different functions, as opposed to interest in the needy.

Now when most people talk about the functions of an ad, they are referring to an ad instead of the sales. They feel people maybe know what except for me, hydrogen talking about secondary being an ad war making a difference between certainly the ad and the interesting ad. And you know, I can continue and talk about them and how each of them functions or wait for your question.


Dr. Joel Rosen: No, Please continue. I think it’s important I’ll just make a distinction for the listener that there’s a difference when you say NAD and how it’s such an important factor for longevity and aging and measuring that usable intracellular different function versus a circulating and I would say that is true with a lot of different nutrients and chemicals and compounds that if it’s intracellular or extracellular because just because it’s there doesn’t mean it’s inside, metabolically proteomic ly changing the cellular activity. So maybe with that please continue in terms of distinguishing the two.


Dr. Jin-Xiong She: Sure. I will start by talking about the function of circulating NAD because NAD IV infusion has been I’m becoming very popular in Iran with the general public, especially in the longevity and wellness community. Now, you know only the IV has been very successfully used to treat various conditions, including new or novel conditions, dementia, Parkinson’s disease, and Alzheimer’s disease, and it’s also a way to the treatment for addiction, including opioid addiction. And you know, success is quite a good a, it has water being used to treat autism.

And it has been used to treat NIGMS disease, a war with, you know, very good success, successful stories, and oh, no, they are no clinical trials, no double-blind in the way biggest research design. But the clinical evidence of the benefit from the needy IV, I think the outfall. However, a lot of people will start using a needy IV. That’s the treatment for longevity and performances.

Um, I’m very sorry to report that only the IV is not really the best modality to even increase interest in the ad. And that has been surprising to many people. And I wouldn’t say that isn’t surprising to me, because of various reasons. And I can go into listing reasons, but the bottom line is, we now have quite extensive data to demonstrate that NAD IV does not increase interest in the NAD, at least in the vast majority of customers. Then, you know, you beg the question, why do you see the clinical evidence by doctors says like an increase in intracellular NAD? How do we reconcile these two? Observation?

And I think that we can explain the observations because an ad is a neurotransmitter. Very few people. Think about them, nobody will talk about it may on receptors for an ad on neuronal cells, immunological cells, immune cells. So that’s why, at least partly why the need for the I V. works quite well, for treating the similar terms that I talked about. Because they either serve as a neurotransmitter, it changed how the neuro network is wired to the war activated.

So that’s, I think that’s so it’s the circulating NAD wasn’t, was the only the other side of the sales letter siblings, I can win your transmitter, and that gave the patients the benefit for knives disease, even COVID. A patient is okay, but not with COVID, a patient or non-COVID patient is getting benefits from an IDI IV. Again, that’s probably through any deal of the Niagen and changes to the immune response. So only B is a very potent anti-inflammatory compound. So, you can explain why unity doesn’t get inside the field.

Mostly you’re interested in ads but still getting all the benefits. So I’m talking about that because I want to predict as well, customers’ patients to understand that if you use the same similar treatment similar compounds. For them, right indications, you’re gonna get a great benefit. But if you use it for the wrong purpose, you’re not going to get the benefit that you want. So it depends on what’s the purpose of the 30 You shouldn’t show to the right to the porch.

You know, for performance for longevity Do you have to boost your interest in an ad, because it is important for energy production, as we’re probably going to talk about them, and why it’s important. And a lot of people can plan, you know, they get tired and don’t perform in the uptake of NAD is really at play. And that’s primarily because of interest in the NAD. So you want to bang, you’re interested in the NAD to the optimum level for gain, and the peak performance in your country is medicine. Right? So choosing in wide approach for the inviter purposes, is extremely important. And I have started to may make people that will need it, and I think this is important, and we need to get the message.


Dr. Joel Rosen: Cool. Yeah, no, thank you for sharing your information. So from what I take I was gonna ask you Well, what counts for the therapeutic benefits extracellularly? And it acts as a neurotransmitter. And there’s a lot of therapeutic benefit for that.

But then at the same time, understand that don’t throw the baby out with the bathwater and say, well, NAD in IVs didn’t work for me, because I expected it to help this or that, because it doesn’t show clinically that it’s gonna boost to intracellular levels, which we’ll get into in terms of not just performance enhancement and longevity, and health span, but I’m sure a whole host of other major metabolic functions that will improve the extracellular effect even further as well, is that correct?


Dr. Jin-Xiong She: Absolutely. And so, with a nod of the when we can put into unity, you are going to get a host of benefits. And then you know, we can go through it. And you know, one by one, you mentioned quite a few of these, you know, improves energy. It protects your DNA from being damaged by oxidative stress and other things. And it was to help people snip, especially deep snip because only the actual in regulates the genes in involved in controlling sleep. And we also have a lot of evidence that posting an ad can improve insulin resistance, and insulin sensitivity, and that’s primarily through, I believe, the reduction of triglyceride.

And you can also reduce the summer divide in them like an IoT. So I think we’re going to discover new functions. And we continue to discover new benefits, you know, constantly, and this is such an important molecule that we can develop not treatment options for given the patient’s or to improve people’s overall health.


Dr. Joel Rosen: Yeah, for sure. I mean I’m sure you’re aware of the statistics that over 88% of Americans are metabolically unhealthy. And I look at the way to explain that as they’re just not respiring at the cellular level, effectively to use oxygen and the food to produce ATP and water. And as a result, they are burning. I guess they’re burning leaves and Kindle and they’re not igniting the log if you will.

I’m curious just to know before you were able to stabilize because you were saying no one tests intracellular NAD. Was it not known that or was just assumed up until that time that actually that IV NAD must boost intracellular and then through actually isolating the intracellular NAD and then retrospectively seeing if they were doing IV shots that it didn’t improve the level? How did you come to learn that? Oh, it doesn’t boost intracellular NAD.


Dr. Jin-Xiong She: Well, so you know, before we got involved, and people were not really making a difference, a distinction between interesting on NAD and secondary NAD and because it’s way hard to measure and especially circulating an ad and it never goes away. No I And, and the NAD in, in the past, MMA is very unstable. And you have a novel in time that can degrade the unity, the Unity molecule, especially, especially CD 38.

So, if you are not careful, if you don’t have writing sample pauses in strategy, you’re not going to be able to imagine, secondly, okay, but very few people were able to measure them, secondly, in AD, and so we kind of stumbled onto it, and I never question that, we wouldn’t be able to post the interesting ad, and we landed by, by data, you know, I’m a data scientist, I have my own opinions, theories about, you know, a lot of things.

But I’m N What I believe is not what I used to think I let the data guide me and make a decision for me, and, you know, I have done a lot of different things. But the one thing that I am proud of myself for is the ability to look at the data and look at data from a global view. And, from a very truthful view, I don’t want to I want my opinion to bias the data. And I think, unfortunately, that’s not what was true, even among scientists. I mean, I’m a scientist, I’m afraid to say that easily.

They don’t understand the data phony, well, they’re kind of biased by their own opinions in either Sunday is good. Till the fourth, never, you have to avoid. So I just look at the data. And the data that we have, from clinical trials that we have done, and from custom data war indicate that an ad IV does not post interest in an ad, there’s no doubt about it. And the black and white even though questionable is no doubt. If you want to want to increase your interest in AD, you got to use a different approach not to IV, right?


Dr. Joel Rosen: Okay, so and to. So basically, it was very difficult to be able to stabilize, whether it was circulating NAD or intracellular NAD. And when you stumbled upon the ability to isolate intracellular NAD, you also know from a scientific point of view, there’s going to be circulating in the blood and it’s going to be sight inside the cell.

And through research and data and inferences. We know without a shadow of a doubt, that giving interest giving IVs with NAD doesn’t impact the intracellular NAD that I’m able to test for. So I guess the two-question part is, how were you able to isolate it? And then number two, what boosts intracellular NAD?


Dr. Jin-Xiong She: Great question. So. So the measurement is way simple. And well, I shouldn’t say way simple for interest on an ad and a little more difficult for circulating an ad. And that’s why we don’t do an auto stimulating ad test because it’s more expensive, and requires shipping in in a container with a cold pack. And it becomes logistically more difficult.

We can we can we can do it and was entrusted in a needy way basically, to a finger prick. And you get a drop of blood onto another car that’s used for newborn screening. We include a small part of a buffer that will call a needy fixing buffer. You try to pull out the card and you fix the NAD and then drop it in, in a mail shipped back to to us in usually within you know five days you will get your data back in your own account in your own secure account is a very simple process. And the performance of the test is great.

The average variation between duplicates is 3.1%. And you know that is great To essay, and I’m very easy to do. So in the second part how what are the best ways to boost interest in an ad? And I’m sure there are going to be many different ways to do it. And so far what I know, is the best way to do it is through NAD precursive. And there are two major types of NAD precursors.

Why is coded in de Cocina, my rival site, and the second one’s called in m en de Cocina, my mono nucleotide? Now it takes them to make an ad from up. So we call in the two-step NAD precursor, it takes only one in them to make an ad from n n n. So we call it one step, NAD precursor. So imagine that there has been a North debate even war between the N camp and the N and N camp. And that’s been going on for years, probably over probably a decade or so.

Okay, I get asked which one works better? Well to choose is both precursors actually work pretty well. And if you have to make a distinguishing, then then n is probably going to work for more people in up Why is necessary. Because imagine that you have a deficiency in the exam that makes N to N m n, then to NAD, your Ni is not going to work because you cannot make an emphasis in law, if you’re deficient in the time to move to make a name for moving up, right.

And even though the internet’s deficient, your Indian men will still work because you don’t need to make it in your work giving in to to the customer, to the patient. So I think that there’s a number the proportion of people who have benefited from nm n should be higher than the percentage of people who can benefit from an up. I don’t know, what’s the proportion?

Okay, that’s the short answer, because I have not done the extensive study on in us and we have done have done within a min and 1000s and 1000s of patients and customers. So we know that n m n is a very good precursor. And it also is not only an N, the non may not be sufficient. And then n inom may not work for many patients, it doesn’t work for many, and it does not work for fairly natural proportion of people as well.

So that’s why you want to formulate the supplements, net highballing MN and then have other ingredients, their health and their mental function. And whatever you want to have ingredients net or booster, the oval war central activity and and that we have actually formulations such supplement that will call it vitality boost. And that can help over 95% of people to optimize the ad. Remember I call the Optimize, not increase, okay, because there is an optimum window of only the level that are probably the best.

And if you get a too much an ad, that may not be good. Well, no, I don’t know the absolute optimum level of the optimum range. But like everything else, too much is not necessarily good. And this is going to be a debate that will continue and I think that we have a lot of data to have unreasonable guidance on wills optimum range shouldn’t be but that will get a fine tune over time and with more data.



Dr. Joel Rosen: Yeah, that’s a great rundown Doctor, thank you for sharing that the way I look at it too, is while it’s an amazing compound to be able to optimize NAD levels, it’s also the perfect storm combination of environmental stressors. And like you said, maybe two steps removed genetic enzyme deficiencies are weaknesses, and you can not just expect the supplement to be a magic one, you still have to address the things I always like to use basic economics demand, and supply.

So if you have weaknesses in the ability to supply it, and that could be dietary things, and it could be in nutrients, and it can be enzymes and so forth. And you have an increased demand to use it up. And that could be DNA breakdown and, and a whole lot of transport enzymes or other like just environmental stressors, then it’s like filling up a cup that’s got a hole in it, you’re never really holding that juiced if you will. And I liked the idea where we do genomic testing to be able to determine what are the weaknesses in your demands.

Meaning what requires more NAD sirtuin challenges, you mentioned CD 38 and inflammatory things we could get into but also DNA breakdown and challenges with X-rays and different types of increased demand for that lifestyle wise and then being able to see potentially, well you know what, you have that gene that doesn’t convert the NR into N MN and why would make no sense for you to take nr you just be yelling at the deaf person louder, expecting them to hear you. So I think that the great thing about where we’re headed is, even though it seems like the sky is falling to a certain extent with EMFs and pollutants, glyphosate, and social media, the stressors just are never-ending.

But then you have a brilliant fellow like yourself that’s coming up with ways to support longevity by testing and what you can track you can manage. And when you can see it in plain white, black, and white, you can improve it. So I appreciate that. So lots of other questions I guess we could talk about in terms of the salvage pathway and the de novo pathway. Did we kind of overlap what we talked about with just mentioning the things we did? Or can we boost both pathways? And what are those and what kind of thing?


Dr. Jin-Xiong She: Yeah, we can so I think that you can for the lay audience, we you know, we don’t have to get into the power with Pettaway what you know what pathways kind of confuses people, I would simply say that they are hard to type in at precursive. I assume that you told me you’re a pretty good guy and I’m gonna put a good guy young Gray.


Dr. Joel Rosen: Like Building blocks kind of thing that you’re talking about building blocks or


Dr. Jin-Xiong She: The building blocks. So So you have the basic building blocks for NAD nicotinamide, and nicotinic acid. And some some people call it the two together with niacin, but most people use niacin nicotinic acid, okay. Even experts sometimes get nice, just the confused to want them to pay attention to it. So I That’s why I avoid use niacin. If I use niacin, I would only use nicotinic acid. Okay. So, it only the molecules basically, the basic element is nicotine amide and then you haven’t labeled and you have nucleotide.

Okay. And we’ll have another one right both in our body and we both have enough amount of nicotine amide but we don’t have enough to make it enough NAD. So many people have thought well we can take a nicotine amide war nicotinic acid and boost the level. And actually, the number of people can get very high levels of NAD. But the problem only a very small proportion of the people can get an ad hire using the very basic elements. They don’t work less efficiently.

MN, for example, By can, you can work for some people. So, and it was in addition, both nicotinic acid and the Bucha might have been the norm, and other health benefits as well, what’s important is to find out whether the strategies that one chooses or chooses are working for them. And we’ll come back to the testing. Without testing, you don’t know whether it’s working for you, or not, what’s the right type of supplement, what the brand of Cybermen and more importantly, how much you should take for you because we’re all built differently.

You know, you talk about the genomics, our genes, our DNA, our differences, and depending on what genes we have, what are the environmental exposures? We have? And what dietary exercise and all these, you know, environmental factors, and the past, our genes never determine how we respond to everything, including how we optimize our NAD. At the end of the day, if you cannot attest, you don’t know what is working or not. And to some individuals is super easy to get their energy very, very high, and even too high with other people is much more difficult.

And so that’s why we developed a test to help people identify what works for them how much they need, without taking too much when they’re not taking enough to weak get needy, optimized, not adjusted only to you know, to not, not all other tests, but we’re talking about needing now we get into the optimize, and you can stay near and have a great time.


Dr. Joel Rosen: Again, it’s a really great answer because everyone is different. Everyone has different stressors, no two snowflakes are the same, right? I mean, whether it’s genetics or environment, there’s no replica of the same factors that will support ad optimization. And so a couple of questions I wanted to get into were the relationship between an ad and biological and chronological age especially because I know you don’t just test NAD intracellular.

You test DNA methylation and you test senescence cells. So I guess it’s a good transition into what is the relationship between NAD and aging aside from what we’ve talked about already, if you don’t have it there, you’re going to age potentially quicker, but how are we using DNA methylation and senescence cells as a proxy and full power that I made because I didn’t plug my computer in before we started so I’m gonna get my computer I’m gonna have the edit this out but I’m gonna be getting my plug so I apologize. No problem.


Dr. Jin-Xiong She: Okay, great. Thank you.


Dr. Joel Rosen: Okay, I’ll make sure we had it that out. So you can start with that with what however you want to start? Yeah.


Dr. Jin-Xiong She: All right. So what was the next question?


Dr. Joel Rosen: We wanted to know the relationship between biological age and chronological age where NAD fits in and also DNA methylation senescence cells what do you do sort what’s the sort of interrelationship


Dr. Jin-Xiong She: Sure. Um, so you know, the chronological age is simple is you know, your your birthday in present time minus your birthday, right? But the chronological age may or may not reflect how you are doing and what’s your power, logical age. You can estimate your biological age by men in different ways. One of the most popular way of measuring biological age is to use DNA methylation, and the test is available from many different companies. They this test can provide a good estimate on what one’s biological age. And we will also provide.


Dr. Jin-Xiong She: About the module age test from our company. But I think it is good information to have, and it can be used to assess what longevity Thereby is providing benefits. I think that is useful information, how well it can do? I’m not so I’m not so sure. And I don’t know whether an ad can influence the methanation age. I don’t have the data yet.

And it’s some it’s a question that we wouldn’t like to answer. But they are suggestions that NAD can extend your telomere names, and your telomeres are the end of the chromosome. And they get shortened over time. And you can use telomeres to measure balance as you age as well. And there is some evidence that anybody can keep the telomere no longer for a longer period.

So that’s why these are still open questions that we needed to study unless a way you know the scientific community. And what we do know is the following. So we know only that is a very good anti-inflammatory compound when discussing that needle. In colonic inflammation is one of the underlying causes of war, chronic diseases. And so keeping inflammation under control. Another good for one’s health, there’s no doubt about it. So we know only the provides a lot of benefit on that.

We also know that NAD can help reduce oxidative stress. Oxidative stress is free radicals that our cells produce. That’s the byproduct. We create energy to create ATP molecules. And that’s just a part of what our sales do. But depending on the settlement conditions, some people produce more free radicals are a waste of the produce nests. Unfortunately, Americans particularly high in oxidative stress, if you look at Caucasians in America versus Caucasians in Europe, European-wide and America-wide, and American whites have much much higher oxidative stress than European white men genetically, they should be comfortable in the lifestyle as you you mentioned.

So if you look at African Americans, the level of oxidative stress is even higher. If you compare Asians now Chinese, I’m Chinese and Chinese from America have much higher oxidative stress than Chinese in China. So something that we do here, the probably the food is particularly bad to create free radicals. And that’s very important. Subhealth issues won’t risk effectively for diseases that way that medical professionals don’t talk about well, it’s a nice don’t talk about enough.

And this is something that I’m I’m very interested in again to you know, get the ideas and To attract people’s attention, you got to pay attention to this free radicals to the oxidative stress. Because bad for our health, and damages our DNA damages our proteins, equate to war kinds of the apartment. Some people even go that far to saying that, you know, oxidative stress or mitochondrial dysfunction, underlying causes of everything. And I think that they are some, you know, good reasoning behind that argument. And it is something that we needed to pay much more attention to.

And the third benefit and that anybody can have is to reduce cellular senescence. Cellular senescence is becoming very popular, not only in the Nativity community, but now it’s starting to gain popularity in the mainstream or Nigerian medical community, because it’s involved in so many different diseases. And we have shown, I’ve shown that senescence determines how cervical cancer patients respond to chemotherapy. And the survival time is not dependent on the cellular senescence level.

And then that’s just one example. So and so these are the three biggest risk factors for health or for disease, chronic inflammation, oxidative stress, cellular senescence, the three biggest and we can take care of these three, and war three are limited to only the level. And finally I want to emphasize and we’ll have a data forward is your only the level external influence will even go as far as the setting determines how you can respond to other therapies, including anti inflammatory, anti senescence, and antioxidative treatment. If you’re only level is not high on optimization, your response to this treatment is much Ness, than otherwise.

So that’s why I’m saying to a lot of people, I mean, even even your listeners don’t remember anything, just remember the next sentence. And optimization is the first and necessary step towards health and longevity. This is the first thing that you want to stress. Because of the influence, so many defensive. Fortunately, we know how to do it now is something that we really can do.

And we just need to make people aware of when and started taking action, I’m trying to convince the people one by one, I spend a lot of my time to talk to, you know, my, my customers and and try to help them to figure out how to get into the optimize, and certainly can get the full benefit of everything else that they try to do to stay healthy. And to stay out of diseases.


Dr. Joel Rosen: No, that’s great Summary Notice if for nothing else continue to optimize your NAD levels through proper lifestyle and nutrition. And I guess what’s amazing with what you’re alluding to is now that we can benchmark and quantify what our actual levels are, and we could manage it. We can also I guess, create protocols before we do certain things like chemotherapy, radiation, and so forth so that you have better outcomes, knowing going into it, that you’re already constitutionally strong, to be able to have a more favorable outcome.

The other thing I’ll say too because I do want to introduce you to what we were talking about earlier, Bob Miller, and help you maybe do some research studies with people that have very low NAD levels. And no matter what you do, they don’t go up, and then being able to see what are these genomic things but one of the things he mentioned to me, which I think resonates with what you were saying with the American male versus the European or the Asian male, is that genetics aren’t different per se very, a very small percentage, but environmentally it is and I think he kind of gave us not the Doomsday, but they like, will look back at some point in time in our environment and say, What were we thinking.

And this is a direct quote in terms of glyphosate and polyesters, and aluminum. And just the list goes on and on and on and on in terms of what we’re doing to our biochemistry that’s depleting our inborn chemistry that ultimately expresses as aging and sickness and hence, that’s why we see so many people falling apart with different exposures to different pathogens and different different, you know, life stressors.

And one thing that I remember you telling me, which I think it’s important to talk about when we were at the firm meeting was that a lot of people who don’t will probably not want to hear this. And you did mention the concept that I guess the fight between the Hatfields and the McCoys or the nm camp and the NMR camp. But also the reality is, is that maybe you can comment on the quality of the nutrient, all things being equal, and how much you need, because a lot of people are hopefully trying to get them up not knowing that the measly amount or the on the standardized source that they’re getting it from, is not going to move the needle. So maybe shed light on that, from your perspective.


Dr. Jin-Xiong She: yeah, no, no, I, you bring up an extremely important question. And we have some answers. So if you look at most supplement companies, including some of the very big ones, and better known, they don’t recommend enough. Okay, so based on our extensive data, I’d recommend 1000 milligrams of Indian and war in to start with, and that’s a good starting point, some people are going to need nests, and other people are going to need more.

But you don’t, you don’t, you don’t want to start up on tunnel or too high. And if the midpoint is 1000, milligram AMI, you can do it, I do the twice a day. And because I like to put my energy and, even more often. So if you want to do the one once a day, that’s fine, but I’d recommend that it twice a day. So what’s interesting is there seems to be a threshold, not that you have to pass to get your own at you, if you don’t pass net a threshold, you are going to get no benefit.

When this benefit. Unfortunately, a huge proportion of people who have been taking the product for sometimes a year, get very needle will no poster will needy because the amount of money that has been taken is not near the threshold. And this threshold is not the same for everyone. Okay, it’s variable. And that’s why you know, we have to test. So once you pass this ratio, you need to never actually jump pretty quickly. If you be known as a straight home, you can wait for a little boost. If you do above this threshold, boom, it goes up.

So that’s no magical solution. Unfortunately, you just have to start with the right dosage and write the product and then get the test in very quickly. And to find out where you are. So you can decide whether you want to increase or decrease the dosage whether you want to switch given the brand or given the type of types of supplements or different types of treatment to get to your level to where you work. And that’s basically what you needed to do. So I have one I have one customer I’m not gonna say his name he’s starting from 100 milligrams a day.

Thank you there are so many tests are with me as I said, why you spending all this money? I mean, he went up from you know, 100 milligram and then he increased by 100 milligram every time I look at To The Test assets you need to need, we need to push it up he either to go up to 1500 milligrams a day. And he kind of has never to over 90 Miko. And then I told him to reduce it a little bit. Now he’s the one the 17, which finished his test yesterday at a 72. Now, we prefer the coveted spot.

So if you’ve been listening to me, I would have had an optimized with the two tests. And within, you know, four to eight weeks. Another misconception is people think that takes a long, long time to get an ad up it No, it’s not true, you only need two to four weeks, and you may people only after a few days, you’re gonna see the level is already high. So most people will reach a very high level after two weeks. And by four weeks, almost everyone reaches a peak. So that’s why I recommend retesting between two and four weeks. You have your level up by two weeks, forget about Memphis, the strategy is now working for you.


Dr. Joel Rosen: You know the analogy I like and you said it earlier were simple guys, we don’t want to go into the weeds per se, we just want to know what we need to do to boost the levels. And the analogy I would use is I don’t get that I haven’t paid my Well, now they’re being paid for. But student loan is a bad example.

But I don’t get why I’m not making a dent in my student loans. Because you’re only making interest payments. That’s why and until you cut into the deficit. And that’s that progressive overload. I’m trained in exercise physiology. And if you do exercises that don’t stimulate any type of response, it’s a no response. If you do a little bit more than what you need, it’s going to be a progressive overload. If you do a lot more than what you need, that difference is going to be a pain.

And I think you want to just not have so much pain with NAD. But you want to do a little bit more than what you need. And then that’s also pointing to the idea of why American men would have lower levels or more oxidative stress and addressing your lifestyle factors and knowing what exposures and what chemicals and what stressors and especially we didn’t get into we’ll do it for part two we’ll leave a little cliffhanger is in terms of one of the major ways that NAD gets depleted is through our nutrient sensing pathways.

And I think the world is catching up on the obesity rates to Americans, if you look at all the different countries now. So I don’t know if we share the prize in that anymore. But maybe we can use that as a segue for the next time that we talk if you’re willing to do in terms of well, how the what’s time-restricted eating? What’s the relationship between a toffee G and eating lots of protein and mTOR? What does that have to do with anything and what do sirtuins have to do with this, so that we can maybe go a little bit deeper for other people?

But the bottom line is to get tested, and know what your levels are so that you can determine and then embark on a prerequisite and building blocks and lifestyle recommendations to boost it, and then get your levels up. And what I liked about your company is that you have on your website that we’ll give links out to the podcast when we publish this if we don’t boost your levels, we will work hand in hand with you to be able to troubleshoot why.

So what I do is I always ask my a question to my guests before we leave, as I say, hey, knowing what you know now, and you’re a smart guy, and I’m sure you’ve always been a smart guy. But you may have not had all this information when you were bright-eyed and bushy-tailed, what would you have told the younger version of yourself that would have helped you or Accelerated your health or just your longevity at an earlier age if you would have known what you know now what would you have told yourself back then?


Dr. Jin-Xiong She: What a very, very good point so, and that one surprise to me was we saw a way sharp and Deputy canine crime of an ad in many people in their native 20s That was shocking. So the point is, you want to start managing your health as early as possible, you know, the twin people in their 20s and 30s I used to be there and they think they are invincible. No, that’s not true. And if you kill yourself, kill yourself healthy, you’re gonna stay healthy for a long, long time. But if we don’t, don’t pay attention to our health and our younger ages, you’re going to pay our dues when we reach old age nears. Now it’s never too early to start paying attention to your health.


Dr. Joel Rosen: Yeah, that’s a great point because you know, you’re seeing, I think for the first time in decades, the lifespan or the age ranges is like life expectancy is going down, I believe. And also type two diabetes is no longer called adult-onset diabetes. And you’re seeing so much more metabolic chaos, if you will, with these kids nowadays, and sleeping with their phone underneath their pillow and Wi-Fi and Amazon Prime and the refrigerator opened at 2 am, and all of these different things that really pull on the purse strings of their longevity and deplete their NAD, it’d be interesting to be able to do a test of 20-year-olds and add in the 19 hundred’s 20-year-olds in the 1920s and then see the NAD levels may be inclined and then decline, I don’t think we’ll be able to do that.

But listen, I appreciate your time. If you have any other questions or points you want to bring in now otherwise, I would love to be able to maybe schedule a part two and then I’m excited to start getting my own NAD levels because I want to be in have integrity with what I do because mine were super low and I’m waiting for my next pure product to come in to be able to boost them and to be able to offer testing to people not just the the the NA intracellular NAD but also looking at some of these other signs of aging and inflammatory weaknesses that need to be addressed. And I’m just really grateful for smart guys like you that offer amazing products and services and information to people that are searching for it. So thank you so much for what you do.


Dr. Jin-Xiong She: Thank you very much. It has been my pleasure to talk to you this afternoon. And your port as well arrives next Monday and I look forward to getting your immediate optimization. I know you’re getting the fear amazing once you get it optimized.


Dr. Joel Rosen: Yeah. Thank you so much. And I’ll talk to you at our next show.


Dr. Jin-Xiong She: Great thanks.

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