Fatigue and G6PD Deficiency Explained with Dr. Bob Miller

 

Dr. Joel Rosen: All right. Hello everyone and welcome back to another edition of the less stress life where we teach exhausted and burnt-out adults the truth about adrenal fatigue so that they can get their health back quickly. I’m joined here with my co-host, Becky roux, who is a moderator and administrator, and creator of the G six PD deficiency support group on Facebook, who suffered from G six PD herself. And now she is developing protocols and research-based information to educate those that need the support. And she’s here to co-host with real special privilege guests that we have with us today.

We’ve interviewed Bob several times. But Bob is the leading edge of healthcare and the way it’s practiced in the year 2021. He is a traditional naturopath, he specializes in genetic-specific nutrition. He opened his Tree of Life practice and has served as a traditional naturopath for 25 years. And for the past several years, he’s been engaged exclusively in nutrient nutritional genetic variations and related research, specializing in nutritional support for those with chronic Lyme.

And I think that needs obviously to be updated because he specializes in people that just are having huge, huge health challenges. And the research that he’s doing is going to enlighten the listener for today’s topic on G six PD. So, Bob, thank you so much for being here. I really appreciate you being here today.

 

Dr. Bob Miller: It’s an honor always a privilege to be with you Dr. Rosen night. And I appreciate all the work you did to help out understand people, their adrenal fatigue and so many things. I know you’re reaching out to a lot of folks for a lot of good work. So congratulations on all you do as well.

 

Dr. Joel Rosen: Oh, well, thank you so much. And it’s all because of the information that I listened to over and over again about what you’re teaching. And I think the listeners are going to get such an amazing piece of the puzzle that they’re not getting because g six PD issues are looked at, as you explain in a way where it’s a genetic thing, hey, do you have the gene?

If you do, then oops, you’re in trouble. And that’s it. That’s all vs. There’s a functional genomic nutrition approach. And that’s really what we’re going to get into today. So how do you want to begin with this?

 

Dr. Bob Miller: Okay, well, firstly, maybe we ought to do just a little bit of genomic one on one and some of the people may not understand, we’re going to be talking about it, we’ll do this very briefly. Firstly, you know, what a miracle we are weed, fats, carbohydrates, proteins, we drink water, breathe air and expose the sunlight. And everything gets made. I mean, every time I say that I sit back. And I think, wow, that’s astonishing. And the reason that happens is that enzymes, take one substance, combine it with something else and make something new, that another enzyme comes along combines that with something, make something new. And that just goes on and on and on.

Your DNA is instructions on how to make the enzymes. So when you hear about the word mutation, or snip or defect, whatever term you want to do, I like to just say major and minor, because I like to say anything is defective, when you have that minor allele, that enzyme production may not be as robust as it should be. So, therefore, the production of one substance to another just may not be as good as it should be. And what we look at from a functional genomic standpoint, is how this can be affecting function. You know, I am not been trained or neither am I a geneticist. I mean, geneticists look at, you know, genes are released to disease, we just look at genetics, health has the potential and let me say keyword potential to impact function.

Because just because you have a mutation, that doesn’t mean for sure something’s happening. But I like to train doctors and say, when you see mutations, it’s something like waving at you like think about looking here. So what we do at functional genomic analysis, is, again, we don’t look at disease states we don’t look at if you’re going to get a disease, we look at me to be making a little too many free radicals may not be making enough in I oxidants, might some of your detox pathways be less than robust as they should be? Are some of your nutrient transports not as robust?

And then there’s a couple of things you can do. If you’re not making enough of something where you can give someone that if the enzymes maybe not at full force, there are nutrients that actually support an enzyme along and if it’s detox, there are ways to support the clearing of the toxins, all goes back to that traditional naturopathic philosophy, the one from a long time ago, that it’s the terrain and you know, on bond, Antoine Bishop was the guy who said to Louis pass tour. Yeah, there are germs but I think it’s the environment that allows the germ to thrive. So Louis passed tour was Let’s kill the germ. Antoine Duchamp said, Let’s change the environment that allows the germ to live there.

So that’s the two sides and of course, you know, they both argued I guess, but the bottom line is they were both correct. We don’t argue we don’t need to argue who’s correct. Everybody is. So we need to clean up the terrain. And unfortunately, you know, I’m 66, and I’m living in a world that I wasn’t born into. When I was a kid, we didn’t have growth hormones given to the animals. We had glass, not plastic. glyphosate wasn’t around yet, cell phones weren’t around yet. genetically modified foods weren’t around yet. So I believe what we’re doing is we are just creating a very toxic environment that we’re living in.

And all of us are being impacted. But for those who have a little bit of genetic weakness, in their ability to create antioxidants or detox pathways, they’re the proverbial canary in the mine that are being hurt the most. So many of these mutations that we have, I often believe that I see people that they’re really sick, and I think, Gee, I wonder if they would have been born 50 years ago, they might not even have a problem. So you know, the adage of the vet genetics, loads the gun, environment pulls the trigger.

And I think we’ve we’re gonna look back someday, with a lot of oops a lot of things that we’ve done. Same, like, we look back on his best, you know, we all meant, well, hey, houses won’t burn down, people won’t die of fire. Oops, you know, all let’s put some lead in the gas, it doesn’t knock as bad. Oops, let’s put some lead in the paint that makes the paint more effective. Oops. And I think we’re going to continue to have many, many more of those.

As, as time goes on, and those who have genetic weakness, as I said, are the proverbial canary in the mines. So that’s the background of what we’re going to talk about today.

 

Dr. Joel Rosen: Yeah, that so when you say the word potential, though, it really minimizes what actually is going on Bob, because you mentioned like, you’re fascinated by the fact that we can take food and different kinds of foods and create reactions and do so many things. And so I think we need to explain the fact that it’s not just the potential that this gene makes this enzyme that does this function, but it’s also knowing how it plays nice with the environment, and what nutrients are needed to be able to make it work properly, and what things can slow it down.

And not only that, but then what’s above it, what’s below it, what’s 3d, what’s diagonal, and understanding all those relationships so that when you do use the word potential, and you are implementing a customized recovery strategy, those potentials add up to have effective results because you’re capitalizing or it’s that enzymatic reaction of one plus one plus one equals 12 or 15, or 20. In your outcomes for sure. So why don’t we go down that rabbit hole as it relates to what uses up NADPH? And how does that get Reese? Reese stimulated almost like a forward feeling forward feeding mechanism where it just it’s it’s in a vicious cycle of just going over and over again, and how that relates to a G six PD person that would be even concerned about that.

 

Dr. Bob Miller: Sure. Well, let’s first talk about NADPH. And as you know, I’ve been intrigued by NADPH for years. No, you’ve got your ad, your ad plus your NADPH. There’s there are several of them. And by the way, if anyone’s a health professional listening to this, we do have an online certification course we have a whole module on an ad NADPH. And we show that, but we’ll just cut right to the chase. I’m sure many people have heard, you know, talks about the importance of FTD. So if you start studying in a deep, you’ll learn how important this is.

Because Firstly, it goes down to Oh, it goes up to NADH, which is at the top of the respiratory training the electron transport for energy. Then an ad also supports the PARP enzymes, which is your DNA repair. So when your cells get damaged, the PARP enzymes need an ad to repair your cells when they’re damaged. Then NAD also feeds what is called the search warrants, which are responsible, they’re part of your anti-aging, and they’re responsible for making your S od and your catalyst. Interestingly, there’s a process called m Tour, which is the growth of new cells, a toughie G, the cleaning of the cells.

And interestingly, NAD stimulates some of the search ones that slow down mtorr and speed up autophagy m Tor being the growth of new cells. And of course, if we didn’t have that the sperm and the egg would never become the baby. The baby never becomes an adult. But if that M tour is running too fast, that can lead to inflammation. quick side note COVID-19 uses mtorr for replication. So it’s important we have this balance between Am torn a toffee G. But then that NAD also becomes NADPH. And that’s where I’m very intrigued. And there’s a lot of genes that are involved that make the enzymes that turn the firstly make an ad, then there are enzymes that turn in AD into NADH for energy.

And there are other genes to turn an ad into NADPH. So let’s now focus on NADPH. It does a lot. Okay. One of the major things we’re going to talk about is how it’s involved in your detoxification of not only free radicals but all the poisons inside the body. So if I can, can I do a screen share here? Oh, yes, abs, please do. Yep. All right, let me do a screen share. That adage, a picture is worth 1000 words here. So. So, again, let’s go back to the naturopathic philosophy, what breaks us down is inflammation. Now, just in case anybody needs to know, everything’s made out of atoms.

So you got the neutron-proton and the electron that spins. And that needs to be electrically balanced. A free radical is when one of those electrons gets ripped off. antioxidants have a spare electron. And I oxidants, neutralize free radicals fairly simple. So qualify own is one of our most important antioxidants. It’s called lithium, or reducible to ion when it’s ready to go. Interestingly, it’s made from cysteine, glycine, and glutamate. These three things go together, these little purple ovals here are enzymes. So these enzymes take the cysteine. Bring it down into white glue says, the GSS gene takes the glycine in this to make lithium.

So many people are aware of this, they even supplement with glutathione and then glutathione well through what’s called glue found conjugation. Take out toxins, anything toxic in the body, particularly even things like mold. Well, after it does its job, it becomes oxidized down here. So that means it’s given away its electron.

Now we need NADPH to take this oxidized qualify back to the reduced. So if we don’t have enough NADPH, your oxidized glutathione doesn’t just sit here. No, it does more. It combines with oxygen to makes what’s called superoxide. Then it combines with nitric oxide, which is a very important gas that we need for circulation. And it makes Ono peroxynitrite. Which is a very oxidizing agent that, ironically will deplete your Bluetooth ion and start damaging your DNA. So that’s why I’m such a fan, of NADPH. Now what can happen then, is you can have mutations on this GSR enzyme.

And this is a pattern that our research is showing continually. We just finished our ninth study on Lyme disease. And perhaps when that’s all finished, we can come back and talk about that. But the bottom line is is that there are more mutations in the GSR enzyme in those with chronic Lyme. I think we’re gonna find the same thing. When we look at mycotoxin toxicity. But GSR is controlled by nerfing two. And nerf two is controlled by keeping one. This is the 3d chess game played underwater. So you can have mutations in keep one that is too strong. Because what keeps one does it holds on to nerf two and releases it. So when you’ve got mutations in keep one, some mutations make it stronger, hold on more tightly than if you got mutations in to nerf two that make it weaker.

Then you’ve got mutations in GSR that make that weaker. And then if you have mutations that you don’t make enough NADPH like g six PD and there’s more than making NADPH but g six PD makes your NADPH you’ve got the proverbial perfect storm that is oxidized glutathione found doesn’t go back to reduce, that’d be a topic for another time would be talking about the A tox one enzyme, this is where we put copper on the S od and that just amplifies the problem. So here you can see that if we don’t have enough NADPH we’re going to have some serious problems taking this oxidized glutathione back to reduction. Now I was I spoke speak to a lot of functional medicine doctors.

And many of they’re saying you know what, Bob? I am noticing that many in the functional medicine world used to give people go to find With good results, they’re having more and more times than they have bad results. So why would that be? Because you would tend to think well, good if I own the master antioxidant, neutralizes your peroxidases take out your toxins, how could that be bad for you? I’ve had many people said their, their health provider just yelled at them. You’re just a hypochondriac, you must be making this up. You can’t be responding poorly to lithium. Well, if you don’t take this oxidized glue found back to the reduced taking glue found too quickly, actually creates inflammation and reduces your solidify.

Oh. So what I’m teaching doctors now when they do functional genomics, is that you really got to look first. Do you have trouble with keeping one nerf two GSR or NADPH g six PD mutations being one of them, that you’re not going to take your oxidized lithium-ion back to reduced? So you can have genetic issues that you don’t make enough NTD and NADPH.

But one of the things that we’ve been talking about for a long time is the phrase I’ve coined and that’s the NADPH steel. I am really intrigued by NADPH. And the reason I am is that NADPH which comes from G six PD is a cofactor for the nos enzyme to make nitric oxide. This won a Nobel Prize for its relationship to circulation. It helps recycle Gouda through dioxin, which is another important you know oxidant that clears the peroxidases we spoke about glutathione it also puts the are on your older iron from him into ferritin turns your heme into biliverdin if needed to turn him into carbon monoxide to stimulate nerf to NADPH has a lot of roles. But this is what really fascinated me. And that is that NADPH does all these good things.

However, there’s a fascinating enzyme called NOx NADPH oxidase fascinating enzyme. And this is part of our immune system. So what happens here is when we are faced with a pathogen, I mean what a miracle the body is, when it sees a pathogen, it says Whoops, you don’t belong here, we need to take you out. This is kind of like our military. And it says Red Alert, Euston, we got a problem we got a foreign invader, we got to take somebody out. So it takes oxygen from iron, an electron from NADPH makes superoxide and hydrogen peroxide, mast cells histamine, the war is on. Okay, the battle has begun. We’re going to take out this bad boy. And if we didn’t have this, we dive into an infection.

I mean, this is a critical part of who we are and how we protect ourselves. However, I believe what’s happening is that many environmental factors, that again, we weren’t exposed to 50 to 75 years ago, are overstimulating the Knox enzyme, overusing NADPH. Consequently, when we use it here, we don’t have it for all of these good things. Now, I’ve not seen any literature on this. So let me just say, this is the bob Miller hypothesis. And that is there’s incredible wisdom in the body. So we tend to think of free radicals as bad. And I oxidants is good, for the most part true.

But we do need free radicals to fight those battles. So if we didn’t have free radicals, we wouldn’t survive. But the problem becomes when the free radicals become excessive. So I think we were designed that when the battle goes on, it would make total sense that you temporarily stop your antioxidant activity to allow the free radicals to do their thing. But if this is chronic, driven by environmental factors, this NADPH is used up. Now talk about a perfect storm. If you’ve got g six PD or other things that limit your NADPH and you’ve got the NOx enzyme upregulated. These are the people that have chronic inflammation. They’ve got all kinds of histamine problems. They’ve got mast cell problems. You know, I find it interesting when I do seminars. Now I’ll ask how many of you doctors have taught more than 20 years?

And I’ll say how many of you saw mast cell problems 20 years ago, and it’s like, we didn’t see how many of you are seeing mast cell problems. Now it’s like, oh my gosh, so many people have mast cell activation syndrome. So these mast cells are our friends. You know, they’re designed to fight the battle. But I believe environmental factors are overstimulating them. And that’s why we’re seeing so much adrenal fatigue, because we need cortisol, to knock down the histamine, which is made by your adrenals. So if you’re constantly making all this histamine, you’re going to wear out your God. There are many things on the adrenals. But this is one of the ways you can wear out your adrenals by desperately trying to fight this histamine battle. And I just see in my health coaching, probably 80% of the people I talked to have high histamine.

And that’s just the tip of the iceberg. And then if you have difficulty, it’s beyond our scope today. But if you have difficulty with histone and methyltransferase, diamine oxidase enzyme glucuronidation, it gets worse. And I think you’ll find this chart fast and fun. Have you seen this one? But if we don’t clear our histamine, it’ll stimulate interleukin six, the cytokine that stimulates the mast cells, and we’ve got a loop that just goes around here. And then the interleukin six makes more superoxide makes more peroxynitrite. We need cloudy on to deal with that. And if we’ve had g six PD deficiencies, and we don’t have enough NADPH, we don’t have enough codifier.

Then what we’ve described as the home cycle, is when superoxide, mast cells, and histamine stimulate the renin enzymes to make more angiotensin, two more interleukins six, and another Merrick around that we’re on here. And we just see this happening so often. So if we look at a chart here, I can actually show you where the G six PD is involved in making the NADPH. So it’s the pentose phosphate pathway, where glucose comes down with ATP. And then we make the NADPH. And then that will support the production. You also have one enzyme that makes NADPH. And then you also have the de novo pathway, where we make the NAD.

And we talked about that how that supports PARP, of how that supports the sirtuins that make many of your antioxidants. And then also another pathway down to NADPH. So that’s, you know, why we need NADPH. And there are many other functions it’s used for. And I believe that environmental factors are using it up. And then if someone has a genetic weakness, they’re more prone to either less production or more of it being used up.

 

Dr. Joel Rosen: Yeah, so so you know, the whole thing I think about again, was the intro of what you just mentioned, in terms of the potentials and then looking at the pathways, if you can do me a quick favor Bob and just scroll it so you can see the whole diagram like with everything that’s involved in what you just described, so you can kind of bring up Okay, so how, how almost everything fits on the screen, so you can see Yes, so here are all the pathways we’re looking at. And ultimately, we are working to understand how this is influencing people that are feeling awful.

In this case with G six PD people, they’re exhausted, they’re tired, they have hemolytic events where they’re their glue defiance depleted, and their red blood cells burst and they get fatigued. But it’s so in my opinion, and again, Joel Rosen opinion is it’s so outdated in terms of well, looking at the diagram we just said, and saying g six PD is one of the ways that make the NADPH and beautify on Pertex, the red blood cells and when Gouda finds depleted, the NADPH doesn’t come back around to help support the Reaper, the Reaper protection, but glutamine ion and NADPH involve the entire diagram he just showed. And so it brings us a whole new way of looking at how do we support this?

How do we because it’s overwhelming? If you look at it, it’s like okay, it said all that now, what do I do about it? How do I dial this down? So what I would ask you, Bob is when you get these potentials and you see these pathways and you understand the NADPH steel, and how the environment impacts that and what the what that 30,000 view foot impact would be on The individual that gets hit the hardest, which is pretty much going to be the same as they’re tired, they’re exhausted, they have no energy, they’re not doing things they would love to be doing. What do you do about it with your, with your coaching clients in terms of Okay, now, it’s just a general question, Bob, in terms of how can we modulate this? How can we slow that home cycle down and NADPH cycle down?

 

Dr. Bob Miller: Sure. Well, one of my favorite sayings is we’ve got to get away from protocols and pills for the ill. Because everyone’s unique. So you could see 10 people in a row with similar conditions, but 10 different ways they got there. So that’s one of my favorite things, we’ve got to say that, you know, we don’t look at the book, oh, this is the protocol that I do for that. I think we’re gonna look back on that as being naive and somewhat outdated. We’ve got to do things personally, for the person. So I think one of the first steps is, you know, one of my favorite sayings is, when the house is on fire, you don’t paint the walls and mow the lawn.

So one of the first places to look is Is there something up-regulating the Knox enzyme, and that can be a little complex. It can be that you over absorb iron. There’s, there are some individuals that have oxalates in case anybody doesn’t know, those are like little razor blades that are in some of the water healthiest foods. When you look at spinach, kale, and beets, if you look at them under a microscope, they have little oxalates in them. They’re sharp little things. So a lot of times people are not feeling well. And they say okay, I’m going to get my act together here, I’m going to eat healthily, and they start doing smoothies.

And they put spinach, kale, and beets in, and it’s like, what the heck, I’m eating healthier, and I’m feeling worse. Hey, when that happens, right? So if you’ve got a leaky gut, those oxalates can leak in. So doing like the Great Plains, your inorganic acid tests can really help you understand whether you have oxalates. So for one person, it might be they need to stop their spinach, kale, and beets smoothies, which just seems so ironic, but that can be one of the factors.

Some individuals particularly have an English Irish, nos, Eskenazi Jewish background, have excess iron absorption. And that iron can drive the NOx enzyme. glutamate is a neurotransmitter that makes you intelligent, highly motivated, go-getter. If it’s in excess, it will drive the NOx enzyme. If you’re a smoker or particularly, a lot of my clients from California when they had the fires, they were getting so sick with upregulated mast cells because of the smoke. aldosterone can do that high homocysteine dopamine. So if somebody has clostridia Clus Tritiya can impact the dopamine and norepinephrine conversion and don’t mean stimulates. For other people, it’s sulfites.

So if they drink a glass of wine, or they do you know, high sulfur foods, they feel horrible. For other people, it’s electromagnetic fields. So all of those things can drive that including interleukin six. And, you know, maybe sometimes we ought to consider doing a webinar just on interleukin six because interleukin six drives the mast cells in the histamine and look at all these things, mold and mycotoxins, Lyme disease, libel, polysaccharides, EMF, and radon. By the way, everybody ought to check the radon in their house. And don’t work next year router, air pollution smoking, sodium sulfate, the heavy metals, glyphosate, the Omega sixes, vo C’s, I mean how many people do we know that?

You know, the new car makes them sick, pesticides, anything that stimulates mTOR inside the body histamine, dopamine and the attention to the Knox enzyme, Brady Keinen obesity and hyperglycemia high homocysteine oxalates that we talked about hydrogen peroxide over-exercise you can actually exercise too much. Interestingly moderate exercise lowers aisle six over exercise increases. I think you said earlier that everything you need to learn you can learn with Goldilocks and the Three Bears you know, not too hot, not too cold. And then virus and anxiety. So all of these will stimulate interleukin six mast cells peroxynitrite and then glue to hf ion has to come to the rescue. And if we don’t have enough NADPH we’re in trouble.

So that’s why NADPH is so important. And it’s the NADPH. I don’t have it on this chart, but the NADPH, helps the NOx enzyme stimulate all that inflammation. So it really is that proverbial 3d chess game played underwater here, Dr. Rosen. And then over on the right here, we have the things that will lower it. But I am just seeing so many individuals have elevated interleukin six. And of course, if you look at the published papers on COVID, interleukin six is involved with, you know, the serious cases of the cytokine storm, I’m sure we’ve all heard the story of the cytokine storm.

And that is elevated interleukin six that makes some of that lung inflammation. Another paper just came out in December that said that people who have aisle six I’m sorry, Knox enzyme, already upregulated are the ones who have more serious reactions to the COVID. Because we know some people get COVID, they didn’t even know they had it. Others have mild symptoms, other people are gasping for breath and dying. So it’s multifactorial, and we don’t oversimplify. But upregulation of NOx and aisle six is a piece of what makes COVID strong. So that’s part of the 3d chess game where we’re looking at here. And if you’d like, would you like to talk a little bit about how fats impact this?

 

Dr. Joel Rosen: Yeah, I definitely would. And I just going to say one comment, Bob because it’s all amazing information. But I know for some of the people sometimes when I explained to ice that I work with and I talked to it’s it’s overwhelming, right? Because it’s they’re not scientists, and they, as much as you’re able to articulate this concept. It’s very complex information. And if I’m exhausted, and I’m tired, and I have G six PD, and I don’t really know what it means, and I don’t really understand what I could do about it. And I just listened to this. And it’s very hard to understand, I think an easy way to summarize that as the environment stimulates an enzyme that helps your body deal with that environment.

And that creates free radicals. And that makes your NADPH that much more needed. And also, at the same time, it’s stimulating your glutathione production to clear out the hydrogen peroxide. And I think that’s the connection that they can come away with Bob, because ultimately, they know that a G six PD person knows and what Becky is teaching in the group, to the G six PD deficiency support group and Facebook is that we need to preserve gluten ion. And if we can preserve gluten fine, and they understand that, but as you said so delicately, if you take too much, it can feed a whole other pathway that creates more free radicals.

So there shouldn’t be an aha in their head thinking, Oh, okay, well, now, I don’t mess I can support the environmental influences on my body that stimulate the depletion of glutamine ion, and the need to have enough NADPH. And when NADPH isn’t around, it’s not going to recycle the gluten ion that is being used up. So that just kind of summarizes that but definitely want to get now into your mitochondria information. Because I’m intrigued not only have I wrote down on my notes like I’m a kid in the candy store every time I talk to you as I need that aisle six pathway so that I can share that with other people because I don’t have that.

Yeah, I just said, you know what a nerd I am, Bob, in terms of how excited I am to get that. But you were talking a little bit earlier about mitochondria and how you think this is the biggest impact that you’ve seen. And listen, when you say something like that to me, I know you’ve said that before about a cat enzyme. You’ve looked at FADS in the past, but you keep coming up with these new I won’t say shiny jeans, but the more like look at me, Jean, that this is a real big domino effect for all physiology in the body.

 

Dr. Bob Miller: Yeah, I believe this might be one of our biggest findings, which brings a good point. I’m sure some people are glazing over at this point. So let me just give you some really quick things to do if you’re dealing with this. Number one, make sure you’re not being exposed to mold. Now, one of the things I often say to people is do you think there’s any mold in the house? Oh, no, I don’t see any mold here. We’re okay. But as you know, yeah, by the way, thank you for participating in our, in our seminar and on mold and, you know, many people don’t realize they can have a mold in the ductwork.

It can just be coming from outside. There can be a leak that mold is up in the ceiling. It can be in the air conditioners. So I hear that all the time. Nope, we don’t have mold. And then we do a mold check and all of a sudden it’s like oh, Do you have mold, you know, something really simple people can do. You can get a little petri dish called mold armor. It’s like eight or 10 bucks. And you just pour a liquid in there, let it gel, let it sit out for an hour, close it for two days. And if you see a lot of growth on there, then you better take mold seriously. There are different parts of the country that I’ve read about. I was stunned, I moved to a new office. And, and I was intrigued by mold, so I buy radon.

So I got a radon detector. And oh my goodness, my new office had radon of 13 should be under two. It’s like no, oops. So we had to get radon mitigation. So and there’s an interesting website radon comm where you can see the average rate on areas where you are. So if someone’s not feeling well, because of G six PD deficiency, as you said, there are things you can do to bring that down, get an air purifier, you know, in my office, I have three air purifiers sitting in here. So make sure you’re drinking pure water. And if you’re smoking, stop smoking. Just simple things. If you think it’s a glyphosate issue, start eating organic, you know, start drinking hydrogen water. Its amazing parsley is so helpful, make sure your vitamin D levels are okay, simple things that that we can all do. But if I had to put it at the top of the list, I’d have to say mold.

Now one of the things that I have observed, now as you know, I’m, I’m probably a little crazy, I do this nine to 11 hours a day, six days a week. And, and I see some of the people that you know, physicians bring people to me, it’s like Bob, we’re stuck. I don’t know what to do anymore. So a lot of my coaching is with physicians who’ve got people that are really ill, and they just don’t know what to do anymore. So we look at their genome and all of a sudden I started seeing a fascinating pattern. Like what the heck is going on here. They’ve got to keep one stronger, nerf two weaker, possibly GSR not strong g six PD or en queue oh one by the way, and qL one is another important enzyme that’s involved with making NADPH.

And if you’ve got g six PD, and then qL one, those can really pile up on you. So then I recognize that the oxidized glutathione is not turning back to the reduced. But I noticed something else. And all of a sudden was like I keep seeing this time after time. There’s an enzyme called fatty acid desaturase and are fads. And what it does, it takes our fats from our diet and turns them into the EPA d h A and then something called protectants and resolvins, which are anti-inflammatory.

If they don’t go down this pathway properly, they will turn into arachidonic acid. And then an interesting collision occurs. The oxidized glutathione combined with the free fatty acids, and there’s an enzyme called 12 lipo oxygenase, that makes 12 HPD and 12 Hiti. Names don’t matter. But the bottom line is it creates mitochondrial dysfunction and oxidative stress. I’m saying publicly I think this is a smoking gun that nobody’s been looking at.

I just see it continually and leaving effect the island function of the pancreas. So we have to wonder is this impacting now this is just hypothetical is impacting pancreatic enzymes. So some of the research we’re doing is to help people who have this how they do on pancreatic enzymes, or lipase, amylase, and protease to see if we can digest those fats better. And then also some supplements are actually the spasms that are already down the pathway here at the protections and results. Now there’s a loss enzyme. Look what this guy does. It stimulates the Knox enzyme. It stimulates tumor necrosis factor and interleukin six, it weakens a toughie G. Whoa. So this my friend, I think is a big deal.

And stay tuned for more on this because I think this might be the smoking gun behind individuals who are struggling. And look what we need to clear this HPD to codify on PR oxidase, another strain on your glutathione. Oops. And we can talk about this at another time, but the superoxide dispute as we spoke about, needs an electron from Bluetooth ion to recycle them. So if you remember, if we don’t take our oxidized blue fi on back to our reduced, we make more superoxide. And even if we’ve got good a tox, one jeans, or plenty of copper, if we don’t have enough glue to tie on, you don’t recycle this guy.

So it’s like having a brand new car with no gas. So in case, anybody’s really confused by now, what I’m talking about here is that if you don’t have enough NADPH, and your oxidized glue found doesn’t go back to the reduced and you don’t have enough superoxide dismutase. That’s when you really do the damage to the body. So stay tuned on that perhaps when we have more of that data together, we want to do a follow-up because we’re in a research stage on that. But for any of the doctors who are watching this, when you see anything that inhibits your oxidized or reduced glutathione inhibits that. And you got fads. These people are just folks who can get out of bed.

They’re intense pain, they’re going from one clinic to another nobody’s figuring out what’s going on. And that’s the merry-go-round they’re on. Now, I think you would ask about, you know, what do we do for this stuff, and I think we kind of went down another bunny trail. My general approach is first if Knox is upregulated, you got to get Knox, calm down. Then if we’ve got problems with nerf two and keep one and GSR, we got to do this. Now even if you have an NADPH deficiency, there’s a nutrient called not divide mononucleotide that supports the production of NADPH.

So it isn’t just an I’ve got D six PD, I’m in trouble, I guess I’m going to be sick the rest of my life, there are things you can do, you can take the strain off the glue to fire them so that you don’t have to use as much you can try to reduce oxidative stress, you can look at things like catalysts to clear hydrogen peroxide, so good if ion doesn’t have to do the job. But it is that 3d chess game played underwater.

 

Dr. Joel Rosen: Again, amazing stuff, Bob. And it really does sum up in terms of the pathways that you develop, to be able to make these potentials. And then as deep in the weeds as you’re getting to understand how it all fits together and creates havoc in the body. Ultimately, if we can help this phase of the cycle to get back up and around to be able to continually replenish itself. We’ll see in general, so many health conditions to be able to be improved by that. It’s just now it’s the work is in doing that so that everything else supports that happening as well, too.

But one of the things I want Becky to say, which was a really good point to what you said earlier, with the FADS how that comes back around and helps with the ability of the Bluetooth ion with the NADPH to get back up with the group that she runs the G six PD that she’s noticed that with most are the research as well, that the hemolysis and the breaking of those red blood cells are shown with the studies to upregulate arachidonic acid.

So but Becky, why don’t you tell us a little bit about what you found and how that relates to what Bob says. And specifically, as we are trying to, from a G six PD point of view, come up with a dietary approach that can harness and be in as Bob says everything you needed to learn was through Goldilocks and the Three Bears be in the Goldilocks zone thereof not too much fat, not too little. Give us a little more implications of that finding.

 

Becky Rhew: Well, as you know, with G six PD, we’re very people are very vulnerable to reactive oxygen species. And the arachidonic acid increases that, absolutely but I’ve also read specifically that in the G six PD deficient cells, they finding a high proportion of the arachidonic acid and lower proportions of palmitic and stearic acid. So I found that to be really interesting, especially when you look at what parts of the world experienced g six PD deficiency in, in high quantity, which is which can be the Mediterranean.

So some of these you know, some of these genetic things are protective in a way and if you’re following the traditional diet where you know where this came about, you might be protected as well. So we have some people from Greece in the group with their g six PD deficient and they have no symptoms. So you know, we can look at maybe their lifestyle is a lot better. This is the US, hopefully. But also maybe they’re following a different type of diet where they’re getting more of that palmitic, stearic oleic acid, and they’re not getting those, you know that that harmful Rise of the arachidonic acid in their cells? It’s very interesting. Yeah.

 

Dr. Joel Rosen: I’d be interested to know to Bob, Becky, and I had talked about this in terms of seeing the differences because we do have cohorts of some Filipino areas and African areas, and Mediterranean areas. And seeing now, which percentage of those people that get hit the hardest, along with their diet happened to have those fA d genes and they’re not even getting the Mediterranean thing I would imagine that the Mediterranean, if they do have the FADS, at least they’re getting more to be able to, to break down from that. versus if you also have that FADS and you live in a country that you don’t need a lot of fat, it’s going to be even more potentially problematic.

But it’d be interesting to research information in that way to be able to see those connections. Yeah, yeah. So as far as the one thing that, you know, I am grateful for your time, but I think it’s really important for you to kind of give us your impression of, and the understanding of that you alluded to it earlier in terms of M tour, and a toughie, G and how important that is, I mean, that’s a whole other seminar. But as far as how what is that? And why, why is that really important and everything we’ve just talked about?

 

Dr. Bob Miller: Sure, well, let’s talk about him toward the growth of new cells. And maybe when I’m chatting here, I can pull up a slide here. So mtorr is the growth of new cells. And if we didn’t have mtorr, life wouldn’t exist. Because the sperm and the egg would never become the baby, the baby would never become the adult. Here’s my slide. There we go. Let me do a screen share. There we go. So here’s my mtorr slide. And this was 2018. presentation at the lime conference in Boston. And we actually found that those with chronic Lyme had more predispositions to an invalid imbalance between them toward a toffee G. So mTOR is the growth of new cells.

And again, that is like a copy machine that causes things to happen. a toughie. g is the cleaning of the cells. So as you know, your cells are constantly dividing. And the old cell when it dies needs to be cleaned out, it needs to be reabsorbed, something called Auto phagosomes that do that, and then they expel the waste through the excretion. And if that doesn’t happen, a good telltale sign of that is when you get age spots prematurely. age spots, sunspots, livers bots, is when the cells aren’t being excluded, they become sentiment. And you know, I’m sure you see people in their mid to late 50s being filled with aid spots, you know, it should be happening to us at all in our 80s. So that’s a sign that the autophagy is not working.

So mtorr is a replication of cells. And it doesn’t care whether it’s a healthy cell cancer cell or COVID, it replicates. And if you look at the chart here, you’ll see xenoestrogens plastics, some people are doing too many amino acids in hormones, I get very concerned when people take the growth factor hormones, glucose and insulin, they can also be driven by EMF, too much iron, too much glutamate. And I think too many people are taking glutamine for their leaky guts, and, you know, causing extra glutamate and Foley. Now we know pregnant women, need to be on fully because if they’ve got particularly mutations that they don’t have enough fully, they can either not get pregnant, have a miscarriage, or deform baby.

So they need the full eight to stimulate that mtorr. But right now, particularly with the environment, we’re living in now, I get a little concerned that some people who are not pregnant might be overtaking too much Methylfolate driving em tour too strongly. So mtorr will inhibit a toughie G. So that’s why we’re seeing such an increase in the popularity of intermittent fasting. Because when you stop the calories, I give the analogy. This is like the construction crew, and you take away the building materials. So when you take away the building materials, it’s like, Okay, guys, break time janitors come out and do your job.

So I believe multiple environmental factors are pushing em tour versus a topology, you know, and one of the things we’re doing I think we’re gonna look back someday and what were we thinking, giving our animals growth hormone so they get fatter faster. Oh my god. We’re gonna look back on that and say, oops. You know, for people my own age, we often talk about, you know, when I was 12 girls look like flat chested little girls. Now 12-year-olds look like 18-year-olds because we’re driving the growth hormone. And we have no idea what the long-term ramifications of that are, as far as cancers and other things.

So that’s why intermittent fasting and the ketogenic diet have been so helpful. But what’s interesting, people who have a lot of mutations in the fads or the pet, crash on the ketogenic diet, can’t handle it, they need carbohydrates on a regular. So a mtorr stimulates interleukin six, which then stimulates mast cells, histamine, superoxide, peroxynitrite, depleting your glutathione.

 

Dr. Joel Rosen: Yeah, I’m one of them. You. I mean, you did mention, but I mean, it’s that it’s just there all the time is the EMF whole other story, but that EMF drives that up and insulin up and mtorr up. One of the other things I would say is on that mtorr diagram, it does stimulate that pentose phosphate pathway that causes that, that makes the NADPH and depletes the G six PD even further. So m tour is really important g six PD people to know how to regulate and Bob, I don’t even think of it anymore, as the crew ever stops working, they don’t go on breaks, they don’t really if you can at least slow the momentum, I don’t even think you put it on pause, let alone off.

I don’t ever think you do. I think it’s past that point. But if you can do fasting, mimicking diets, and other things that will help berberine and things that can stimulate an NPK, there are so many things that can be done about that, which is why we do the information we’re doing. But ultimately, to your point, though, everything in balance, because if that mTOR is not being stimulated, it’s not making the NADPH either. So at the same time, we need to really learn how to balance this, but your information is always amazing. And I’m, again, just thank you for everything you do. Because, I think you are humble in the way that you say, potential so that, you know, it doesn’t mean it’s going to happen. But we understand the depth of these pathways, and you’re deep in the woods and really impacting the way health care is being practiced.

And ultimately, you have successes. And that’s the thing, the sky is not falling, we have the ability to harness what we know, information-wise. And, Bob, you’re a living testament to that you just said six days a week, 1112 hours a day. And so it and your brain are still really sharp and amazing. So thank you for everything you do. You know, ultimately, there are a lot of providers listening to this, and you did mention your conferences, I’d be curious to know if you’re having any live ones coming up because I’d love to be at your next one live. But ultimately, how do well how does it work if I’m a provider, and I had a lot of aha moments in this call, and how do I learn more?

 

Dr. Bob Miller: Sure, we decided we were going to wait until we can know if we’re going to have a live conference. So we may just push it off to spring of next year. Virtual is fine. But it’s, as one doctor said it’s so nice to see each other’s naked faces live. So we’re going to see if we can have a live conference in the spring of 2022. But if somebody wants to learn about our online certification courses, just go to functional genomic analysis.com, functional genomic analysis.com. And right there, you can go into my online certification course. Now, this is for physicians or other health professionals. And the first couple of modules are free. And then, of course, we have our own genetic test.

We have our own spit kit, we have our own online software, we’ve put about $2.5 million into the development, we’re continuing to roll out advances. So we want to be of help to the health professional. So we have medical doctors, we have traditional we have naturopaths who do this work. And if someone’s a health professional listening to this, I want to just say that the reports we make are not for the faint of heart. If somebody thinks they’re going to get a two-page report that says do this. No, you’ve got to do your homework. You got to learn the pathways.

And but the software does give you suggestions as to, you know, where you need help and we’re putting in what are called dynamic messages all the time so that there’s actually going to be messages that will come up from me that will be like You know what, you’ve Mqone and G six PD, but you also have an RF two. So I don’t think we spoke about that, but nerf two controls g six PD and n q one. So you know, that’s why I think some people might be able to have a Gsix PD and they’re fine. Other people are more impacted. So if you’ve got the G six PD weakness in nerf to upregulation and keep one, then those g six pts might be a whole lot more important.

So again, we like to simplify things, Gene problem, I think we’re going to have to abandon that someday. And see that is that 3d chess game played underwater, multiple snips, multiple environmental factors. And so if you’ve got g6pd, and you live in mold, and you’re a smoker, and you’re under chronic stress, and you just got over Lyme disease, you’re going to be a whole lot harder than the person who doesn’t do that eats organically, meditates or does whatever for stress. So there are multiple factors, and I think we’re gonna find there aren’t simple solutions.

 

Dr. Joel Rosen: That’s the beauty of it all, as complex as this gets the simple solution is the common-sense solution. And, you know, what, what you should be doing anyway. And so just to thank you once again, and to echo the fact that when you have the the the gene snips, it’s a very reductionistic approach, as you’ve listened from this going forward. It’s interesting, as well, Bob, because I listened to some of our old talks. And you’ve mentioned, like, I think someday we’ll look back and think that was naive of us as the doctor, right. And I think that you continue to grow that knowledge base to be able to understand and give hope and provide solutions.

So and there is an effective solution. So if you’re a provider listening to that, I highly recommend that because as you mentioned, last and pat in finalizing is, you now work mostly with doctors that are not knowing what to do at this point, because it is so complex. So when you open up that blueprint of the functional genomic analysis, and you see all those things, you have these light bulbs saying, hey, look here, look here. And you’re now doing research studies over time to see these correlations. And it’s not just the other what you just mentioned, there hit harder with a tox.

Now, that would make it worse for a FADS. So now you can put in your software, hey, as soon as a tox comes up, and it goes down the superoxide pathway, let’s let them know that that’s something we need to consider too. So that’s awesome information. Bob, really, really great. Thank you so much for spending the time and helping people with G six PD, get some more information, and ultimately empower them to be able to know that it’s not a gavel of the ground and granted that this is a problem for you forever. You are empowered to be able to do something about it.

 

Dr. Bob Miller: Absolutely. Well, it’s been a lot of fun. I’ve enjoyed it like always and glad to come back anytime you want me.

Dr. Joel Rosen: Awesome. Thank you so much, Bob.

 

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