Your Adrenal Fix Podcast Episode #3: What Else is Missing? The Adrenal Fatigue “X”-factor

What Else is Missing”? Learn About the “X”-Factor, That Every Adrenal Fatigue Sufferer MUST Learn

 How your genes may be to blame!

What We Are Going To Cover:

92% of chronic condition sufferers who have genetic testing, haven’t been properly explained their results and how that relates to their adrenal fatigue. What 4 Tests That Both Your Primary Doctor or Natural Doctor Are Not Ordering, That You Must Have To Help Boost Energy…Naturally. How Your Own Unique Environmental Stressors Must Be Incorporated Into Your Treatment Plan. How Your Nutritional Program is Not a One-Size Fits All Strategy, And How Pulsing Nutrients, and Living Under the Bell Shaped Curve is The Way To Go.

What is Adrenal Fatigue?

Adrenal fatigue is when the function of the glands output of hormone is not regulated based on stress responses. Adrenal fatigue can wreak havoc with your life. In serious cases, the activity of the adrenal glands is so diminished that you may have difficulty getting out of bed for more than a few hours per day. With each increment of reduction in adrenal function, every organ and system in your body is more profoundly affected.

How your genetics may be to blame?

  • COMT, MAO, PNMT, DBH
  • Breakdown of catecholamines/dopamine = loss of feedback mechanisms
  • CYP1B1, CYP21
  • Conversion of cortisol from 17-OH Progesterone
  • SRD5a, SRD5b, 11b-HSD
  • Cortisol metabolism
  • MTHFR
  • Not enough gas in the tank to regulate a stress response
  • Breakdown of Dopamine/Catecholamines
  • Cortisol Metabolism
  • Cytochrome P450 Enzymes

Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.Genetic variants can slow the function of hydroxylase enzymes resulting in slowing of synthesis of cortisol

Cortisol Metabolites

SRD5a/5b – cortisol reductase enzymes that convert cortisol into tetrahydrocortisol , a metabolite of cortisol. 11bHSD (11 Beta hydroxysteroid dehydrogenase – enzyme that converts cortisol into cortisone and corisone into cortisol. Factors that affect these enzymes include thyroid dysfucntion, dysglycemia/insulin resistance, inflammation, insomnia, fatty liver

Methylation Pathway Starts The Party for This Whole Adrenal Fatigue Standpoint

The Methionine Methylation Cycle

  • Removes Toxins
  • Eliminates Free Radicals
  • Protects B12
  • Supports Immune Function

Methylation

The way the body deals with stress is called methylation.

  • Promotes Detoxification
  • Controls Inflammation
  • Balances Neurotransmitters

If methylation is not performing efficiently, key bodily functions can not be performed effectively. These abnormal by-products can lead to high levels of inflammation in the body, which can result in mood and emotional changes as well as liver, pancreas, thyroid, stomach, intestinal, adrenal, and hormone imbalances.

Methyl groups are VITAL for normal cell replication.

  • Turn genes, enzymes “on” or “off”
  • Depleted methyl groups
  • Bad genes turn on – Oncogenes
  • Good genes turn off – Tumor Suppressor genes
  • Good genes can become mutated
  • Methyl groups come from stomach acid
  • Proper MTHFR expression is needed for proper Methylation
  • MTHFR is an enzyme in the methylation cycle that converts 5,10MTHF to 5-MTHF

Methylene-tetrahydrofolate reductase

The MTHFR enzyme is vital for many biochemical processes in the body and is a major player in the methylation cycle. A genetic problem interferes with your body’s ability to break down folic acid into methylfolate, leading to a decrease in methylfolate production, methyl B12 production, and SAMe (S-Adenosyl Methionine). Deficiencies in active folate can cause many chronic neurological and metabolic health conditions

What is your Doctor Missing in relationship to adrenal fatigue?

What doctors are missing when it comes to determining if you have adrenal fatigue.

  • Genetic testing beyond MTHFR
  • 23andmeLiveWello, MTFHRSupport, Nutrhacker, Genetic Genie
  • Functional Genetics and the best test for adrenal fatigue
  • Adrenal fatigue – DUTCH Test (Cortisol metabolities)
  • Organic Acids
  • Methylation Pathway Testing – SAM, SAH, Cysteine, Homocysteine, Methionine
  • NeuroBiogenic Amines
  • Epigenetics

The environment and lifestyle drive the genetics. Genetic mutation are not the be all end all. Detoxification and lifestyle changes have to be made. Do not just treat SNPs. How are the following factors preventing your recovery? Bacteria, Virus, Candida/Fungal, Mold, Parasites, Xenobiotics/Environmental Toxins, Heavy Metals, EMFs

Living Under the Bell Shape Curve

  • Where to start?
  • Start slow and layer or work up?
  • If your feeling worse?
  • If your feeling better?

Over methylation can happen immediately or over a longer time. If you are looking for relief of your adrenal fatigue nightmare, click here to work one on one.